Acrylamide → Phenidone

HRID 2393342ノート

反応式

HRID 2393342 の反応式
[C:1]1([NH:7][NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:9](N)(=[O:12])[CH:10]=[CH2:11].[OH-].[K+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[C:1]1([N:7]2[CH2:11][CH2:10][C:9](=[O:12])[NH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 6579AcrylamideHCID 7516PhenylhydrazineHCID 14797Potassium Hydroxide

生成物 1

HCID 7090Phenidone

試薬・触媒・溶媒 1

HCID 74236Tetrabutylammonium Bromide触媒

実験手順

Phenylhydrazine (10.8 g, 0.1 mol), and acrylamide (7.8 g, 0.11 mol), pulverized potassium hydroxide (12.5 g, 0.22) and a catalytic amount of tetrabutylammonium bromide is refluxed for 30 minutes. The precipitate is filtered and washed with toluene. The crystalline sold is dissolved in water. Acidification with acetic acid, filtration and drying gives 1-phenyl-3-pyrazolidone.

後処理

  1. filtrationThe precipitate is filtered
  2. washwashed with toluene
  3. dissolutionThe crystalline sold is dissolved in water
  4. filtrationAcidification with acetic acid, filtration
  5. customdrying

出典と根拠

ORDレコード
ord-a82caac1fad34dcb8cdc22597bbf516d
出典データセット
uspto-grants-1998_09
特許番号
US05807863

反応ノート

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