4-クロロトルエン (1mg/mlメタノール溶液) [水質分析用]

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Do NOT induce vomiting. Refer for medical attention .

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. /Chlorotoluenes/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.

AVOID PROLONGED BREATHING OF VAPOR. USE WITH ADEQUATE VENTILATION.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to knock-down vapors. /Chlorotoluenes/

Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Chlorotoluenes/

Chlorotoluene, an isomeric mixture predominantly of ortho- and para-monochlorotoluene with up to 6 percent unreacted toluene and a boiling range of 110 °C to 162 °C, is exempted from the reqiurement of a tolerance when used as a solvent or cosolvent in pesticide formulations with the following restrictions: (a) Not for use after edible parts of the plant begin to form. (b) Do not graze livestock in treated areas within 48 hrs after application. /Chlorotoluene/

Quantitative structure-activity relationship estimates of toxicity of narcotic chemicals for 19 species of bacteria, algae, fungi, protozoans, coelenterates, rotifers, molluscs, crustaceans, insects, fish, and amphibians were used to predict no-effect levels at the ecosystem level by means of recently developed extrapolation methods. Equilibrium partitioning theory was used to derive no effect levels for aquatic sediments and internal toxicant concentrations for aquatic organisms. A simple table is given from which no effect levels for narcotic chemicals for water, sediment, and residues in biota can be predicted on the basis of only the octanol/water partition coefficient and molecular weight. The method may be applied to setting quality criteria for the aquatic environment and to ecotoxicological interpretation of (bio)monitoring data. Calculations were carried out for 102 narcotic compounds.

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 340(SRC), determined from a measured water solubility(2) and a recommended regression-derived equation(3), indicates that 4-chlorotoluene will have moderate mobility in soil(SRC). Volatilization of 4-chlorotoluene may be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 4.4X10-3 atm-cu m/mole(SRC), determined from experimental values for vapor pressure(4) and water solubility(2), and from dry soil surfaces(SRC) based on an experimental vapor pressure of 2.79 mm Hg(SRC), determined from experimentally-derived coefficients(4). Based on limited data, 4-chlorotoluene may biodegrade aerobically in soil under some conditions(SRC). 4-Chlorotoluene at 20 mg/l, was 44% and 64% biodegraded in three days using a river water and a seawater inoculum, respectively(5). However, at 100 ppm, 4-chlorotoluene showed only 0(6)-<30%(7) biodegradation in 14 days using an activated sludge inoculum. An isolated strain of Pseudomonas putida 39/D, oxidized 4-chlorotoluene to (+)-cis-4-chloro-2,3-dihydroxy-1-methylcyclohexa-4,6-diene(8); 4-chlorotoluene is metabolized via cis-dihydrodiol(9).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 340(SRC), determined from a measured water solubility(2) and a recommended regression-derived equation(1), indicates that 4-chlorotoluene may adsorb to suspended solids and sediment in the water(SRC). Based on limited data, 4-chlorotoluene may biodegrade aerobically in water under some conditions(SRC). 4-Chlorotoluene at 20 mg/l, was 44% and 64% biodegraded in three days using a river water and a seawater inoculum, respectively(3). However, at 100 ppm, 4-chlorotoluene showed only 0(4)-<30%(5) biodegradation in 14 days using an activated sludge inoculum. An isolated strain of Pseudomonas putida 39/D, oxidized p-chlorotoluene to (+)-cis-4-chloro-2,3-dihydroxy-1-methylcyclohexa-4,6-diene(6); p-chlorotoluene is metabolized via cis-dihydrodiol(7). 4-Chlorotoluene should volatilize from water surfaces based on an estimated Henry's Law constant of 4.4X10-3 atm-cu m/mole(SRC), calculated from experimental values for vapor pressure(8) and water solubility(2). Estimated half-lives for a model river and model lake are 4 hours and 5 days, respectively(1,SRC). BCF values from 14 to 101.6(4), measured in carp, indicate that 4-chlorotoluene may moderately bioconcentrate in aquatic organisms(SRC), according to a recommended classification scheme(9). Based on monitoring data from the River Rhine, the half-life of 4-chlorotoluene in a river 4-5 m deep during mid-summer was estimated to be 1.2 days(10).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 4-chlorotoluene, which has a measured vapor pressure of 2.79 mm Hg at 25 °C(2), determined from experimentally-derived coefficients, should exist solely as a vapor in the ambient atmosphere. Vapor-phase 4-chlorotoluene is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 9 days(3,SRC).

Dry skin. Redness. Pain.

Redness. Pain.

Identified in chlorinated leachate from a simulated landfill lysimeter used to study codisposal of metal plating sludge with municipal solid waste(1). Identified as a principal organic hazardous constituent (POHC) in the emissions from an incinerator test burn(2). 4-Chlorotoluene was detected in the volatile organic fraction from compost samples from eight solid waste composting facilities with a maximum concentration of 240 ug/cu m(3). 4-Chlorotoluene was detected in 5 of 5 hazardous waste sites in New Jersey at concentrations ranging from 0.04-0.71 ppbv; 4-chlorotoluene was detected in the volatile organic emissions of a sanitary landfill which received only non-hazardous industrial and municipal waste at an average concentration of 0.03 ppbv(4). Thermal decomposition of vinylidene chloride polymers (food wrapping film) resulted in the formation of 4-chlorotoluene at an average concentration of 11.2 ug/g(5). 4-Chlorotoluene was detected in the leachate of fabric used for the manufacture of collapsible potable water storage tanks at 0.3 ug/l following exposure to low pH conditions(6).

The Koc of 4-chlorotoluene is estimated as approximately 340(SRC), using an experimental water solubility of 106 mg/l at 20 °C(1,SRC) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that 4-chlorotoluene will have moderate mobility in soil(SRC).

Acute oral toxicity was evaluated in groups of 2 adult male albino Sprague-Dawley rats administered para-chlorotoluene by gavage as either a 1.0 or 10% volume/volume solution in corn oil or in undiluted form at dosage levels of 10, 31.6, 100, 316, 1000 or 3160 ul/kg. Mortality was observed in both rats in the 3160 ul/kg dose group (100% solution) and the LD50 was estimated to be 1780 ul/kg. Clinical observations included depression, lacrimation, labored respiration, ataxia, tremors, depressed righting and placement reflexes and prostration. Gross necropsy revealed congestion of the lungs, kidneys and adrenals and inflammation of the gastrointestinal tract in the decedents. Sacrificed animals did not display this inflammation.

Acute oral toxicity was evaluated in groups of 5 male and 5 female fasted Sprague-Dawley rats administered 4-chlorotoluene by gavage at a level of 1.7, 2.3, 3.3 or 4.6 g/kg. Mortality was observed in 2 males in the 1.7 g/kg group, 3 males and 4 females in the 2.3 g/kg group, and in all 5 males and females in the 3.3 and 4.6 g/kg groups. The LD50 was determined to be 2.1 g/kg (1.8 - 2.4 g/kg). Clinical observations included a decrease in motor activity, tremors, cyanosis, piloerection, excess salivation, chromodacryorrhea, increase in respiratory rate, decrease in respiratory rate and lacrimation. Gross necropsy revealed bright red or red and mottled lungs, stomach and intestinal irritation and cream colored, white or dark fluid in the stomach and intestine, red stained fur around the nose, "blanched" stomachs and fluid filled stomachs.

Acute dermal toxicity was evaluated in 2 male and 2 female New Zealand white rabbits exposed to a single occluded dose of undiluted parachlorotoluene to abraded and intact skin. There were no mortalities and an LD50 value was not reported. Clinical and necropsy observations revealed nothing remarkable except for diarrhea in 1 male.

p-Chlorotoluene (CAS # 106-43-4) was evaluated for chromosomal effects. A single intraperitoneal injection of 1000 mg/kg body weight was administered to male and female mice. Animals were sacrificed and femoral marrow was prepared at 16-hours (5 M, 5 F); 24-hours (5 M, 5 F); and 48-hours (5 M, 5 F) after administration. Signs of toxicity included apathy, roughened fur, staggering gait, spasm, twitching, shivering, and difficulty in breathing. Two animals died during treatment. Gross necropsy revealed slightly inflated lungs and spotted livers. The ratio between polychromatic and normochromatic erythrocytes and clastogenic effect was not altered.

July-Aug 1981: Newark, NJ, 38 samples, 95% pos, mean concn 0.21 ppb; Elizabeth, NJ, 37 samples, 97% pos, mean concn 0.25 ppb; Camden, NJ, 35 samples, 97% pos, mean concn 0.22 ppb(1). Jan-Feb 1982, Newark, NJ, 28 samples, 96% pos, mean concn 0.17 ppb; Elizabeth, NJ, 38 samples, 92% pos, mean concn 0.14 ppb; Camden, NJ, 37 samples, 78% pos, mean concn 0.07 ppb(1). During 1983-84, detected in air samples collected at 6 hazardous waste sites in NJ, mean concn range <0.03-0.70 ppb, and one sanitary landfill in NJ, mean concn 0.04 ppb(2). Chlorotoluene isomers (o-, m-, and p-): Love Canal in Niagara Falls, NY, 15 samples, 80% pos, concn range trace-12,274 ng/cu m(3); Love Canal, 10 samples, 50% pos, concn range <0.010-1.64 ng/cu m(4); Baton Rouge, LA, 11 samples, 9% pos, 35 ng/cu m(3).

Human air pollution inhalation season ploy cyclic aromatic hydro carbon mutagenesis sulfate space heating motor vehicle exhaust.

4-Chlorotoluene's production and use as a solvent and intermediate in the synthesis of organic chemicals, dyes(5), pharmaceuticals, and synthetic rubber chemicals(3) may result in its release to the environment through various waste streams(SRC). 4-Chlorotoluene may be formed in the environment as a photodegradation product of 4-chlorobenzyl chloride(4), an intermediate used in the manufacture of pharmaceuticals, dyes and other organic chemicals(1,2,SRC).

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Benzene, 1-chloro-4-methyl is included on this list.

Chlorotoluene, an isomeric mixture predominantly of ortho- and para-monochlorotoluene with up to 6 percent unreacted toluene and a boiling range of 110 °C to 162 °C, is exempted from the reqiurement of a tolerance when used as a solvent or cosolvent in pesticide formulations with the following restrictions: (a) Not for use after edible parts of the plant begin to form. (b) Do not graze livestock in treated areas within 48 hrs after application. /Chlorotoluene/

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). These standards implement Section 111 of the Clean Air Act and are based on the Administrator's determination that emissions from the SOCMI cause, or contribute significantly to, air pollution which may reasonably be anticipated to endanger public health or welfare. The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. p-Chlorotoluene is produced, as an intermediate or final product, by process units covered under this subpart. These standards of performance become effective upon promulgation but apply to affected facilities for which construction or modification commenced after January 5, 1981.

(CA) CALIFORNIA 140 ug/l

(NH) NEW HAMPSHIRE 100 ug/l

(ME) MAINE 140 ug/l