Diethyl Carbonate → Ethyl p-toluate

HRID 65129

反応式

HRID 65129 の反応式
[C:1]1([CH3:8])[CH:6]=[CH:5][C:4](Cl)=[CH:3][CH:2]=1.[C:9](=O)([O:13]CC)[O:10][CH2:11][CH3:12]>S1(CCCC1)(=O)=O.CC1C(CN2CCC(N3CCC(N4C(=O)NC5C4=CC=CC=5)CC3)CC2)=CC=CC=1>[C:1]1([CH3:8])[CH:6]=[CH:5][C:4]([C:9]([O:10][CH2:11][CH3:12])=[O:13])=[CH:3][CH:2]=1

参加物

5

反応物 2

HCID 7766Diethyl CarbonateHCID 78104-Chlorotoluene

生成物 1

HCID 66743Ethyl p-toluate収率 78%

試薬・触媒・溶媒 2

HCID 10092649Tbpb触媒HCID 31347Sulfolane溶媒

反応条件

温度
170 °C

実験手順

A mixture of 7.73 g of p-toluyl chloride, 5.91 g of diethyl carbonate, and 0.85 g of TBPB in 25 ml of sulfolane was heated at 170° C. under reflux. After 44 hours, the reaction mixture was added to 200 g of crushed ice and this was extracted twice with 25-ml portions of hexane. The combined extracts were dried over anhydrous Na2SO4 and distilled to obtain 6.4 g (78 percent yield) of ethyl p-toluate, b.p. 120°-1° C./20 mm.

後処理

  1. temperatureunder reflux
  2. extractionthis was extracted twice with 25-ml portions of hexane
  3. dry with materialThe combined extracts were dried over anhydrous Na2SO4
  4. distillationdistilled

出典と根拠

ORDレコード
ord-89c4edfe301549e2a78b54d2663f85b5
出典データセット
uspto-grants-1986_09
特許番号
US04612386

関連ノート

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