Glutaric anhydride (HCID 7940)

概要

Glutaric anhydride is a cyclic dicarboxylic anhydride that is oxane which carries oxo groups at positions 2 and 6. It is used as an intermediate in the production of pharmaceuticals, corrosion inhibitors, and polymers (E.g. epoxy polyesters). It is a cyclic dicarboxylic anhydride and a member of oxanes. It is functionally related to a glutaric acid.

名称と識別子

優先名称: Glutaric anhydride
IUPAC: oxane-2,6-dione
現地名: グルタル酸無水物
英語名: Glutaric anhydride
分子式: C5H6O3
分子量: 114.1

名称と別名

GLUTARIC ANHYDRIDE108-55-4Dihydro-2H-pyran-2,6(3H)-dioneoxane-2,6-dionePentanedioic anhydrideGlutaric acid anhydridePyroglutaric acid2H-Pyran-2,6(3H)-dione, dihydro-Pentanedioic acid anhydrideAnhydrid kyseliny glutaroveDTXSID504436263OFI15S80

名称をさらに表示

グルタル酸無水物無水グルタル酸ペンタン二酸無水物3,4-ジヒドロ-2H-ピラン-2,6(5H)-ジオンテトラヒドロ-2H-ピラン-2,6-ジオンジヒドロ-2H-ピラン-2,6(5H)-ジオンジヒドロ-2H-ピラン-2,6(3H)-ジオン無水グルタル酸, 98%GANGlutamic AnhydrideTETRAHYDROPYRAN-2,6-DIONEutaric anhydrideGlutaric anhydridpyroglutaricacidGlutarsureanhydrid

NSC-166402H-Pyran-2,6(3H)-dione, dihydroDTXCID3024362CHEBI:167482RefChem:143700203-593-6MFCD00006679dihydro-3H-pyran-2,6-dione

データベース識別子

CAS: 108-55-4
PubChem CID: 7940
DTXSID: DTXSID5044362
ChEMBL: CHEMBL3188341
ChEBI: CHEBI:167482
UNII: 63OFI15S80
EC Number: 203-593-6
Nikkaji: J49.215I

物性

構造計算による物性

XLogP: -0.1
極性表面積: 43.4 Å²
水素結合供与体数: 0
水素結合受容体数: 3
回転可能結合数: 0
重原子数: 8
形式電荷: 0
複雑度: 114

実験および物理化学的性質

PolymersPlastics & Rubber -> Acid Anhydrides, Cyclic

SpringerMaterials PropertiesBoiling point

Physical Description · 2 件

CBI; Dry Powder

Off-white flakes or crystals; [Alfa Aesar MSDS]

物理化学的性質

融点: 50 · 50-55 °C (lit.)
沸点: 150 °C/10 · 150 °C/10 mmHg (lit.)
比重(密度): 1 · 1,411 g/cm3
蒸気圧: 0.05 hPa · 0.05 hPa (50 °C)
屈折率: 1.463 · 1.4630 (estimate)
闪点: 230 °F · >230 °F
貯蔵温度: 30 °C · Store below +30°C.
溶解性: クロロホルム、酢酸エチル
外見: 結晶性粉末または結晶
色: ホワイトからオフホワイト
水溶解度: 加水分解
BRN: 110051 · 110051
InChI: 1S/C5H6O3/c6-4-2-1-3-5(7)8-4/h1-3H2
InChIKey: VANNPISTIUFMLH-UHFFFAOYSA-N
SMILES: O=C1CCCC(=O)O1
CAS データベース: 108 · 108-55-4(CAS DataBase Reference)
NISTの化学物質情報: 2 H-Pyran-2,6 · 2H-Pyran-2,6(3H)-dione, dihydro-(108-55-4)
EPAの化学物質情報: 2 H-Pyran-2,6 · 2H-Pyran-2,6(3H)-dione, dihydro- (108-55-4)

化学的性質

化学的特性beige to light brown crystalline powder

安全と法規制

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 0.4% (1 of 270) of reports.

Danger

H302 (98.5%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 270 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 4 件

Chemical: 2H-Pyran-2,6(3H)-dione, dihydro-

2H-Pyran-2,6(3H)-dione, dihydro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2H-Pyran-2,6(3H)-dione, dihydro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 27-09-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/11130

Glutaric anhydride: Does not have an individual approval but may be used under an appropriate group standard

Hazards Summary · 1 件

Causes somnolence, necrotic gastrointestinal changes, and diffuse hepatitis in oral lethal-dose studies of rats; [RTECS] An irritant that may cause serious eye injury; Toxic by ingestion and skin absorption; [Alfa Aesar MSDS] See Acid Anhydrides.

Hazard Classes and CategoriesAcute Tox. 4 (98.5%)

毒性情報

Adverse EffectsOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

安全データ

F: 2-21
wgk: 3
tsca: TSCA listed
rtecs: MA3850000
ridadr: 3261
hs_code: 29171990
risk_code: 21/22-37/38-41-36/37/38-20/21/22
化審法: (2)-3431
hazard_code: Xn
safety_code: 26-36/39-36/37/39-36
hazard_class: 8
packing_group: Ⅲ
自然発火温度: 320 °C
Hazard Classifications: Acute Tox. 4 OralEye Dam. 1Skin Irrit. 2
ストレージクラス: 11 - Combustible Solids

化学と産業

用途と製造

UsesUsed to make fine chemicals; [ExPub: ECHA REACH Registrations]

U.S. Production2023: 75,000 - <500,000 lb

Consumer UsesFragrance

Industry UsesNot Known or Reasonably Ascertainable

General Manufacturing Information · 2 件

Not Known or Reasonably Ascertainable

2H-Pyran-2,6(3H)-dione, dihydro-: ACTIVE

応用分野

用途有機合成原料。

上流・下流製品情報

上流原料

アジピン酸シュウ酸 Dehydrolyzing agent グルタル酸こはく酸グルタリルクロリド

下流製品

5-OXO-5-(2-THIENYL)VALERIC ACID 4-ベンゾイル酪酸ブスピロングルタル酸モノメチル 5-(2-チエニル)ペンタン酸バクロフェン Pentanoic acid, 5-hydroxy-, 1,1-dimethylethyl ester (S)-4-フェニル-3-[5-(4-フルオロフェニル)-5-オキソペンタノイル]-2-オキサゾリジノン 5-メチルヘキサン酸エチルグルタリルクロリド 5-[ビス(2-ヒドロキシエチル)アミノ]-1-メチル-1H-ベンズイミダゾール-2-ブタン酸エチルエステル 4-(2-ベンズイミダゾリル)酪酸

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国药集团化学试剂有限公司86-21-63210123 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

衢州润东化工有限公司0570-8789886 18892685668 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

INTATRADE GmbH+49 3493/605464 · [email protected]

グルタル酸無水物

基本情報

概要