Glutaric anhydride → 4-[(3-Ethynylphenyl)carbamoyl]butanoic acid

HRID 19458

反応式

HRID 19458 の反応式
[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2]1.[C:9]([C:11]1[CH:12]=[C:13]([CH:15]=[CH:16][CH:17]=1)[NH2:14])#[CH:10]>ClCCl>[C:9]([C:11]1[CH:12]=[C:13]([NH:14][C:5]([CH2:4][CH2:3][CH2:2][C:1]([OH:7])=[O:8])=[O:6])[CH:15]=[CH:16][CH:17]=1)#[CH:10]

参加物

4

反応物 2

HCID 7940Glutaric anhydrideHCID 104682Benzenamine, 3-ethynyl-

生成物 1

HCID 435292404-[(3-Ethynylphenyl)carbamoyl]butanoic acid収率 99%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Glutaric anhydride (215 mg, 1.9 mmol) was dissolved in anhydrous dichloromethane (7 ml) and followed by the addition of 3-ethynylaniline (200 mg, 1.7 mmol). The mixture was allowed to stir at room temperature for 6 hours before the solvent was evaporated under reduced pressure to provide the product as a white solid (363 mg, 99%);

後処理

  1. customwas evaporated under reduced pressure

出典と根拠

ORDレコード
ord-b51d7cb6b41e41718e3f39d76b7da4bc
出典データセット
uspto-grants-2010_06
特許番号
US07745229B2

関連ノート

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