Tricine (HCID 79784)

名称と識別子

優先名称: Tricine
IUPAC: 2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid
現地名: N-[トリス(ヒドロキシメチル)メチル]グリシン
英語名: Tricine
分子式: C6H13NO5
分子量: 179.17

名称と別名

Tricine5704-04-1N-Tris(hydroxymethyl)methylglycineN-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycineGlycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-W12LH4V8V32-((1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)amino)acetic acidNSC-3699952-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acidDTXSID1063982CHEBI:39063n-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine

名称をさらに表示

N-[トリス(ヒドロキシメチル)メチル]グリシンN-[1,1-ビス(ヒドロキシメチル)-2-ヒドロキシエチル]グリシントリシンN-[2-ヒドロキシ-1,1-ビス(ヒドロキシメチル)エチル]グリシンカルボキシメチルアミノメチリジントリメタノール1,3-ジヒドロキシ-2-(ヒドロキシメチル)プロパン-2-イルアミノ酢酸N-[1,3-ジヒドロキシ-2-(ヒドロキシメチル)プロパン-2-イル]グリシンN-トリス(ヒドロキシメチル)メチルグリシントリシン, 98+%トリズマ®バッファー物質TRIS-HCL BUFFER1389475TROMETHAMINE HYDROCHLORIDETicineTricine buffer, free acidTRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDETRIClNEn-Tricine-D8

2-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}acetic acidGlycine, N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)-RefChem:899271DTXCID6042159CHEBI:467602-((1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)azaniumyl)acetate227-193-6N-[Tris(hydroxymethyl)methyl]glycine

データベース識別子

CAS: 5704-04-1
PubChem CID: 79784
DTXSID: DTXSID1063982
ChEBI: CHEBI:39063
UNII: W12LH4V8V3
EC Number: 227-193-6
Nikkaji: J135.902I

物性

構造計算による物性

XLogP: -5.1
極性表面積: 110 Å²
水素結合供与体数: 5
水素結合受容体数: 6
回転可能結合数: 6
重原子数: 12
形式電荷: 0
複雑度: 137

実験および物理化学的性質

Physical DescriptionSolid; [Merck Index] White crystals; [Sigma-Aldrich MSDS]

物理化学的性質

融点: 186 · 186-188 °C (dec.)
沸点: 311.69 °C · 311.69°C (rough estimate)
比重(密度): 1.05 g/mL · 1.05 g/mL at 20 °C
蒸気圧: 0.002 · 0.002-0.004Pa at 20-25℃
屈折率: 1.424 · 1.4240 (estimate)
貯蔵温度: Keep in dark place,Inert atmosphere,Room temperature
溶解性: 2 O: · H2O: 4M at20℃、透明、無色
外見: 結晶性
色: 無色透明 (40% (w/w) in H2O) 溶液
臭い (Odor): 無臭
PH: 4 · 4.0-6.0 (1M in H2O)
酸解離定数(Pka): 8.1 · 8.1(at 25℃)
由来生物: synthetic
水溶解度: 溶ける
Merck: 14 · 14,9651
BRN: 1937804 · 1937804
安定性: 安定。
InChI: 1S/C6H13NO5/c8-2-6(3-9,4-10)7-1-5(11)12/h7-10H,1-4H2,(H,11,12)
InChIKey: SEQKRHFRPICQDD-UHFFFAOYSA-N
SMILES: OCC(CO)(CO)NCC(O)=O
LogP: -2.87 at · -2.87 at 25℃
CAS データベース: 5704 · 5704-04-1(CAS DataBase Reference)
EPAの化学物質情報: 2 · Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]- (5704-04-1)
Absorption: 0.05 at · ≤0.05 at 280 in H2O at 1M≤0.1 at 260 in H2O at 1M

化学的性質

化学的特性White/clear crystalline powder

安全と法規制

GHS分類

GHS Classification · 3 件

This chemical does not meet GHS hazard criteria for 97.6% (121 of 124) of all reports.

Not Classified；Reported as not meeting GHS hazard criteria by 121 of 124 companies (only 2.4% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 124 reports by companies from 4 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 121 of 124 reports by companies.；There are 3 notifications provided by 3 of 124 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory Information · 3 件

Chemical: Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-

Status: Active Update: 02-03-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/25731

Glycine, N-2-hydroxy-1,1-bis(hydroxymethyl)ethyl-: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to environment

Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS]

Hazard Classes and CategoriesNot Classified

法規制情報

Regulatory Information · 3 件

Chemical: Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-

Status: Active Update: 02-03-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/25731

Glycine, N-2-hydroxy-1,1-bis(hydroxymethyl)ethyl-: Does not have an individual approval but may be used under an appropriate group standard

安全データ

F: 3
wgk: 3
tsca: TSCA listed
hs_code: 29052900
risk_code: 36/37/38
hazard_code: Xi
safety_code: 26-36-36/37/39
ストレージクラス: 13 - Non Combustible Solids

化学と産業

用途と製造

UsesUsed as a biological buffer; [Merck Index]

General Manufacturing InformationGlycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-: ACTIVE

応用分野 · 2 件

使用Good's buffers Tricine is used as an electrophoresis buffer and involved in the separation of low molecular weight proteins and peptides. It operates in the pH range between 7.4 and 8.8. It acts as an effective scavenger of hydroxyl radicals during the study of radiation-induced membrane damage. It is also used in resuspension of cell pellets. It is a zwitterionic amino acid commonly useful in the pH range of 7.4-8.8 and the pKa is 8.05 at 25°C. This buffer is also used as an eluent in asymmetrical flow field-flow fractionation (AFFFF).

一般的な説明Tricine and its salts are used as biological buffers to control the pH of body fluids in vitro and in vivo. It acts as a precursor for polymers, oxazolones (with carboxylic acids), and oxazolidines (with aldehydes). Trizma can serve as an alkalizing agent in treating acidosis of the blood.

調製方法

純化方法Crystallise Tricine from EtOH and water. [Good et al. Methods Enzymol 24B 53 1968, McGothlin & Jordan Analyt Lett 9 245 1976, Beilstein 18 III/IV 3454.]