N-[トリス(ヒドロキシメチル)メチル]グリシン
Tricine
基本情報
- CAS
5704-04-1- 標準SMILES
O=C(O)CNC(CO)(CO)CO- InChIKey
SEQKRHFRPICQDD-UHFFFAOYSA-N- 分子式
- C6H13NO5
- 平均分子量
- 179.17 g/mol
- 単同位体質量
- 179.07937252
概要
N-tris(hydroxymethyl)methylglycine is a Good's buffer substance, pKa = 8.15 at 20 C. It is functionally related to a glycine and a member of tris. It is a tautomer of a N-tris(hydroxymethyl)methylammonioacetate.
名称と識別子
- 優先名称
- Tricine
- IUPAC
- 2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid
- 現地名
- N-[トリス(ヒドロキシメチル)メチル]グリシン
- 英語名
- Tricine
- 分子式
- C6H13NO5
- 分子量
- 179.17
名称と別名
Tricine5704-04-1N-Tris(hydroxymethyl)methylglycineN-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycineGlycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-2-((1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)amino)acetic acidW12LH4V8V3NSC-3699952-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acidDTXSID1063982CHEBI:39063n-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine
名称をさらに表示
N-[トリス(ヒドロキシメチル)メチル]グリシンN-[1,1-ビス(ヒドロキシメチル)-2-ヒドロキシエチル]グリシントリシンN-[2-ヒドロキシ-1,1-ビス(ヒドロキシメチル)エチル]グリシンカルボキシメチルアミノメチリジントリメタノール1,3-ジヒドロキシ-2-(ヒドロキシメチル)プロパン-2-イルアミノ酢酸N-[1,3-ジヒドロキシ-2-(ヒドロキシメチル)プロパン-2-イル]グリシンN-トリス(ヒドロキシメチル)メチルグリシントリシン, 98+%トリズマ®バッファー物質TRIS-HCL BUFFER1389475TROMETHAMINE HYDROCHLORIDETicineTricine buffer, free acidTRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDETRIClNEn-Tricine-D8
2-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}acetic acidGlycine, N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)-RefChem:899271DTXCID6042159CHEBI:467602-((1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)azaniumyl)acetate227-193-6N-[Tris(hydroxymethyl)methyl]glycine
データベース識別子
- CAS
5704-04-1- PubChem CID
- 79784
- DTXSID
DTXSID1063982- ChEBI
CHEBI:39063- UNII
- W12LH4V8V3
- EC Number
- 227-193-6
- Nikkaji
- J135.902I
物性
構造計算による物性
- XLogP
- -5.1
- 極性表面積
- 110 Ų
- 水素結合供与体数
- 5
- 水素結合受容体数
- 6
- 回転可能結合数
- 6
- 重原子数
- 12
- 形式電荷
- 0
- 複雑度
- 137
実験および物理化学的性質
Chemical ClassesOther Uses -> Biological Buffers
Physical DescriptionSolid; [Merck Index] White crystals; [Sigma-Aldrich MSDS]
物理化学的性質
- 融点
- 186 · 186-188 °C (dec.)
- 沸点
- 311.69 °C · 311.69°C (rough estimate)
- 比重(密度)
- 1.05 g/mL · 1.05 g/mL at 20 °C
- 蒸気圧
- 0.002 · 0.002-0.004Pa at 20-25℃
- 屈折率
- 1.424 · 1.4240 (estimate)
- 貯蔵温度
- Keep in dark place,Inert atmosphere,Room temperature
- 溶解性
- 2 O: · H2O: 4M at20℃、透明、無色
- 外見
- 結晶性
- 色
- 無色透明 (40% (w/w) in H2O) 溶液
- 臭い (Odor)
- 無臭
- PH
- 4 · 4.0-6.0 (1M in H2O)
- 酸解離定数(Pka)
- 8.1 · 8.1(at 25℃)
- 由来生物
- synthetic
- 水溶解度
- 溶ける
- Merck
- 14 · 14,9651
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 97.6% (121 of 124) of all reports.
Not Classified
Aggregated GHS information provided per 124 reports by companies from 4 notifications to the ECHA C&L Inventory.
危険有害性情報
Regulatory Information
Chemical: Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-
REACH registered substance: N-(tri(hydroxymethyl)methyl)glycine (EC: 227-193-6)
Glycine, N-2-hydroxy-1,1-bis(hydroxymethyl)ethyl-: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to environment
Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesNot Classified
安全データ
- F
- 3
- wgk
- 3
- tsca
- TSCA listed
- hs_code
- 29052900
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36-36/37/39
- ストレージクラス
- 13 - Non Combustible Solids
化学と産業
用途と製造
UsesUsed as a biological buffer; [Merck Index]
General Manufacturing InformationGlycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-: ACTIVE
応用分野
使用Good's buffers Tricine is used as an electrophoresis buffer and involved in the separation of low molecular weight proteins and peptides. It operates in the pH range between 7.4 and 8.8. It acts as an effective scavenger of hydroxyl radicals during the study of radiation-induced membrane damage. It is also used in resuspension of cell pellets. It is a zwitterionic amino acid commonly useful in the pH range of 7.4-8.8 and the pKa is 8.05 at 25°C. This buffer is also used as an eluent in asymmetrical flow field-flow fractionation (AFFFF).
一般的な説明Tricine and its salts are used as biological buffers to control the pH of body fluids in vitro and in vivo. It acts as a precursor for polymers, oxazolones (with carboxylic acids), and oxazolidines (with aldehydes). Trizma can serve as an alkalizing agent in treating acidosis of the blood.
調製方法
純化方法Crystallise Tricine from EtOH and water. [Good et al. Methods Enzymol 24B 53 1968, McGothlin & Jordan Analyt Lett 9 245 1976, Beilstein 18 III/IV 3454.]
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