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リチウムブロミド

Lithium Bromide

HCID 82050
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基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
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基本情報

CAS
7550-35-8
標準SMILES
[Br-].[Li+]
InChIKey
AMXOYNBUYSYVKV-UHFFFAOYSA-M
分子式
BrLi
平均分子量
86.9 g/mol
単同位体質量
85.93434165

概要

Lithium bromide is a lithium salt in which the counterion is bromide. The anhydrous salt forms cubic crystals similar to common salt. It is a bromide salt and a lithium salt.

名称と識別子

優先名称
Lithium Bromide
IUPAC
lithium bromide
現地名
リチウムブロミド
英語名
Lithium bromide
分子式
BrLi
分子量
86.85

名称と別名

Lithium bromide7550-35-8Lithium monobromideLithium bromide (LiBr)bromolithiumLITHIUM BROMATUM864G646I84CHEBI:63042DTXSID20892222RefChem:55513DTXCID801079305231-439-8
名称をさらに表示
臭化リチウムリチウムブロミド臭化リチウム無水臭化リチウム(無水)臭化リチウム [一般有機合成用]臭化リチウム(無水),3N5臭化リチウム ANHYDROUS,FREE-FLOWING,REDI-DRITM,REAGENTPLUS,≥99%臭化リチウム PURISS. P.A.,≥99.0% (DRIED MATERIAL,AT)臭化リチウム REAGENTPLUS,≥99%臭化リチウム, 無水/ 99+%臭化リチウム/ 99.995+%臭化リチウム 溶液臭化リチウム (99.95%-Li) (0.2% H2O)臭化リチウム, 無水, 99% min臭化リチウム, 無水, 99.99% (metals basis)臭化リチウム, 無水, 99+%臭化リチウム, 無水, 99.995% (metals basis)LITHIUM HALIDEAnhydrous lithiuM broMideithium bromideLithiumbromide,dihydrateLITHIUM BROMIDE ANYDROUSLithium bromide, extra pure, 99.999%Lithium bromide anhydrous, free-flowing, Redi-Dri, ReagentPlus, >=99%
LITHIUMBROMIDELiBrlithium;bromideBrLiLithium bromide anhydrousLITHIUM BROMIDE, ANHYDROUSMFCD00011077LIthium bromide solution

データベース識別子

CAS
7550-35-8
PubChem CID
82050
DTXSID
DTXSID20892222
ChEBI
CHEBI:63042
UNII
864G646I84
EC Number
231-439-8
Nikkaji
J43.853G

物性

構造計算による物性補完中

極性表面積
0 Ų
水素結合供与体数
0
水素結合受容体数
1
回転可能結合数
0
重原子数
2
形式電荷
0
複雑度
2

実験および物理化学的性質

Chemical ClassesMetals -> Metals, Inorganic Compounds
SpringerMaterials Propertiesdielectric constant
Density3.464 @25 °C
Melting Point550 °C
Physical Description · 2 件

Dry Powder; Wet Solid; Dry Powder

Highly deliquescent white solid; [Merck Index] White powder, crystals, or beads; Hygroscopic; [Alfa Aesar MSDS]

物理化学的性質

融点
550 °C · 550 °C (lit.)
沸点
1265 °C · 1265 °C
比重(密度)
1.57 g/mL · 1.57 g/mL at 25 °C
蒸気圧
1 hPa · 1 hPa ( 748 °C)
闪点
1265 °C · 1265°C
貯蔵温度
Inert atmosphere,Room Temperature
溶解性
メタノール（微量、加温）、水（微量）
酸解離定数(Pka)
2.64 · 2.64[at 20 ℃]
外見
粉
比重
3.464 · 3.464

安全と法規制

安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。

GHS分類

GHS Classification · 6 件

Warning

H302 (98.2%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P272, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 279 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]

危険有害性情報

Regulatory Information · 4 件

Chemical: Lithium bromide (LiBr)

Lithium bromide (LiBr) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Lithium bromide (LiBr) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 13-03-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/13642

Lithium bromide: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Lithium bromide (LiBr): Human health tier I assessment
Hazards Summary · 1 件

Causes flaccid paralysis with appropriate anesthesia, tetany, and arrhythmias in oral lethal-dose studies of mice; [RTECS] High doses may cause CNS depression and disturbed blood electrolyte balance; Chronic exposure may cause skin eruptions and adverse CNS effects; [Merck Index] A skin and strong eye irritant; Harmful by ingestion; [Alfa Aesar MSDS] See Lithium and Bromine.

Hazard Classes and Categories · 4 件

Acute Tox. 4 (98.2%)

Acute toxicity (Oral) - Category 4

Skin sensitization - Category 1B

化学と産業

薬理情報

Metabolism/Metabolites · 1 件

Bromine is mainly absorbed via inhalation, but may also enter the body through dermal contact. Bromine salts can be ingested. Due to its reactivity, bromine quickly forms bromide and may be deposited in the tissues, displacing other halogens. (L626)

FDA Pharmacological Classification · 2 件

LITHIUM BROMATUM

Mood Stabilizer [EPC]

用途と製造

UsesUsed as a humectant and sedative/hypnotic; [Merck Index]
U.S. Production2023: 100,000 - <250,000 lb
Consumer UsesNot Known or Reasonably Ascertainable
Industry UsesIntermediate
General Manufacturing Information · 2 件

Petroleum Refineries

Lithium bromide (LiBr): ACTIVE

応用分野 · 3 件

用途冷媒、脱水剤、乾燥剤、空調機器の加湿剤、鎮静剤や催眠薬などの医薬品

使用As humectant, in air-conditioning systems. An aqueous solution of lithium bromide containing about 50 % lithium bromide is used as an absorbent in large-scale absorption air conditioning equipment. Lithium bromide is also used in limited amounts by the pharmaceutical industry for dehydrobromination of organic compounds to form olefins.

一般的な説明LiBr/Chlorotrimethylsilane reagent participates in the conversion of alcohols to bromides.

調製方法 · 3 件

関連反応

948 件
反応記録を作成
HRID 2542 の反応式
HRID 2542反応物としてuspto-grants-1998_03
HRID 2576 の反応式
HRID 2576反応物としてuspto-grants-1998_03
HRID 6283 の反応式
HRID 6283反応物としてuspto-grants-1993_09
HRID 9736 の反応式
HRID 9736反応物としてuspto-grants-2006_08
HRID 11999 の反応式
HRID 11999触媒としてuspto-grants-2010_06
HRID 18710 の反応式
HRID 18710反応物としてuspto-grants-2010_06
HRID 23784 の反応式
HRID 23784反応物としてuspto-grants-2005_02
HRID 31556 の反応式
HRID 31556反応物としてuspto-grants-2008_09
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化合物ノート

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このページの内容基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
その他の操作
ノートを作成反応を作成見積依頼を出す
色
白い
PH
7 · 7 (20°C, 10g/L)
臭い (Odor)
無臭
水溶解度
61 g/100mL · 61g/100mL(25℃)
Merck
14 · 14,5526
安定性
安定。無水形態は非常に吸湿性があります。
InChI
1S/BrH.Li/h1H;/q;+1/p-1
InChIKey
AMXOYNBUYSYVKV-UHFFFAOYSA-M
SMILES
[Li+].[Br-]
LogP
-0.37 at · -0.37 at 25℃
CAS データベース
7550 · 7550-35-8(CAS DataBase Reference)
NISTの化学物質情報
Lithium bromide(7550-35-8)
EPAの化学物質情報
Lithium bromide (7550-35-8)
化学的性質 · 2 件

化学的特性White cubic crystals; hygroscopic; refractive index 1.784; density 3.464 g/cm3; melts at 550°C; vaporizes at 1,265°C; highly soluble in water (145g/100g at 4°C), much greater solubility in hot water (254g/100g at 90°C); soluble in methanol, ethanol and ether; slightly soluble in pyridine; vapor pressure of aqueous solutions at 52 and 68% concentrations at 25°C are 5 and 0.7 torr, respectively.

化学性质潮解性，融点547℃，沸点1265℃

Acute toxicity (Oral) - Category 4

安全と保護具

Exposure Control and Personal Protection0.2 [mg/m3], inhalable fraction, as Li[German Research Foundation (DFG)]
Protective Action Criteria (PAC) · 3 件

1.5 [mg/m3]

17 [mg/m3]

100 [mg/m3]

毒性情報

Treatment · 1 件

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

Health Effects · 1 件

Bromine vapour causes irritation and direct damage to the mucous membranes. Elemental bromine also burns the skin. The bromide ion is a central nervous system depressant and chronic exposure produces neuronal effects. This is called bromism and can result in central reactions reaching from somnolence to coma, cachexia, exicosis, loss of reflexes or pathologic reflexes, clonic seizures, tremor, ataxia, loss of neural sensitivity, paresis, papillar edema of the eyes, abnormal speech, cerebral edema, delirium, aggressiveness, and psychoses. (L625, L626, L627)

Adverse EffectsNeurotoxin - Other CNS neurotoxin
Exposure RoutesOral (L626) ; inhalation (L626) ; dermal (L626)
Toxicity Summary · 1 件

Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and produce tissue damage. In additon, the formation of hydrobromic and bromic acids will result in secondary irritation. The bromide ion is also known to affect the central nervous system, causing bromism. This is believed to be a result of bromide ions substituting for chloride ions in the in actions of neurotransmitters and transport systems, thus affecting numerous synaptic processes. (L626, L627, A543)

Signs and Symptoms · 1 件

Bromine vapour causes irritation and direct damage to the mucous membranes. Symptoms include lacrimation, rhinorrhoea, eye irritation with mucous secretions from the oropharyngeal and upper airways, coughing, dyspnoea, choking, wheezing, epistaxis, and headache. The bromide ion is a central nervous system depressant producing ataxia, slurred speech, tremor, nausea, vomiting, lethargy, dizziness, visual disturbances, unsteadiness, headaches, impaired memory and concentration, disorientation and hallucinations. This is called bromism. (L626, L627)

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Toxicity DataLD50: 1800 mg/kg (Oral, Rat) (L661) LD50: 1680 mg/kg (Subcutaneous, Mouse) (L660)

安全データ

F
3
wgk
2
tsca
TSCA listed
rtecs
OJ5755000
hs_code
28275900
risk_code
32-40-43-36/37 -36/37/38 -36/38
化審法
(1)-110
hazard_code
Xi
safety_code
22-26-60-24/25-36/37-36/37/39
Hazard Classifications
Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2Skin Sens. 1
ストレージクラス
13 - Non Combustible Solids

製造方法Lithium bromide may be prepared by the reaction of lithium hydroxide monohydrate or lithium carbonate with hydrobromic acid. The resultant solution of lithium bromide may be evaporated and cooled to crystallize a hydrate of lithium bromide, the composition of which depends on the final temperature. The lithium bromide hydrate may be filtered from the mixture and carefully dried by the application of heat in a vacuum desiccator to avoid melting the hydrate.

合成方法炭酸リチウムと臭化水素酸から得られた水和物を加熱脱水する

純化方法Crystallise it several times from water or EtOH, then dry it under high vacuum for 2 days at room temperature, followed by drying at 100o. Its solubility in H2O is 167% at ~20o, and 250% at ~100o. It is deliquescent and should be stored in a tightly stoppered vessel.

上流・下流製品情報

上流原料

Iron filingsリチウムヒドロキシド炭酸ジリチウム臭化水素酸臭素

下流製品

2-(3-BROMO-PROPYL)-1H-BENZOIMIDAZOLE[[(2E)-1-メチレン-3-メトキシ-2-プロペニル]オキシ]トリメチルシラン臭化ナトリウムトリス(トリメチルシリル)シラン水素化ホウ素リチウムトリ-tert-ブチルホスフィンブロモトリス(トリフェニルホスフィン)ロジウム(I)

補足説明

定義ChEBI: A lithium salt in which the counterion is bromide. The anhydrous salt forms cubic crystals similar to common salt.