Hydrochloric Acid → [4-Cyano-2,3-bis-[(2-methoxy-ethoxy)-methoxy]-phenyl]bromoacetic acid

HRID 2576

反応式

HRID 2576 の反応式
[CH:1]([Br:4])(Br)Br.[Br-].[Li+].[OH-:7].[K+].[C:9]([C:11]1[CH:18]=[CH:17][C:14](C=O)=[C:13]([O:19][CH2:20][O:21][CH2:22][CH2:23][O:24][CH3:25])[C:12]=1[O:26][CH2:27][O:28][CH2:29][CH2:30][O:31][CH3:32])#[N:10].Cl.[O:34]1[CH2:39]COCC1>C(OCC)(=O)C.O>[C:9]([C:11]1[CH:18]=[CH:17][C:14]([CH:1]([Br:4])[C:39]([OH:34])=[O:7])=[C:13]([O:19][CH2:20][O:21][CH2:22][CH2:23][O:24][CH3:25])[C:12]=1[O:26][CH2:27][O:28][CH2:29][CH2:30][O:31][CH3:32])#[N:10]

参加物

9

反応物 6

HCID 313Hydrochloric AcidHCID 5558BromoformHCID 14797Potassium HydroxideHCID 312751,4-DioxaneHCID 82050Lithium BromideHCID 183590784-Cyano-2,3-bis-[(2-methoxy-ethoxy)-methoxy]-benzaldehyde

生成物 1

HCID 18359186[4-Cyano-2,3-bis-[(2-methoxy-ethoxy)-methoxy]-phenyl]bromoacetic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

440 microliters of bromoform were added at -5° C. to a mixture of 4.26 mg of lithium bromide, 598 mg of potassium hydroxide and 5 ml of water and then, a solution of 825 mg of a 4-cyano-2,3-bis-[(2-methoxy-ethoxy)-methoxy]-benzaldehyde (preparation given hereafter) in 5 ml of dioxane was added dropwise. The mixture was stirred for 72 hours at 0° C. to -5° C. and was poured into a stirred mixture at 0° C. to -5° C. of 15 ml of ethyl acetate and 11 ml of hydrochloric acid. Extraction was carried out with ethyl acetate and the extracts were washed, dried and evaporated to dryness under reduced pressure. The oil obtained was used as is for the following step.

後処理

  1. extractionExtraction
  2. washthe extracts were washed
  3. customdried
  4. customevaporated to dryness under reduced pressure
  5. customThe oil obtained

出典と根拠

ORDレコード
ord-a2d6a5f5e06e41cb9bec46be781f750a
出典データセット
uspto-grants-1998_03
特許番号
US05728828

関連ノート

読み込み中…