(+-)-Methionine

HCID 876CAS 26062-47-5

基本情報

標準SMILES: CSCCC(N)C(=O)O
InChIKey: FFEARJCKVFRZRR-UHFFFAOYSA-N
分子式: C5H11NO2S
平均分子量: 149.21 g/mol
単同位体質量: 149.05104977

名称と識別子

優先名称: (+-)-Methionine
IUPAC: 2-amino-4-methylsulfanylbutanoic acid
英語名: POLY-L-METHIONINE
分子式: C5H11NO2S
分子量: 149.21

名称と別名

DL-METHIONINE59-51-8RacemethionineAcimetionLobamineUrimeth(+-)-MethionineDL-MethioninumMethionine, DL-2-amino-4-methylsulfanylbutanoic acid2-amino-4-(methylsulfanyl)butanoic acidFEMA No. 3301

名称をさらに表示

Nsc118113Poly(Met)polymethioninePOLY-L-METHIONINEPOLY-L-METHIONINE USP/EP/BP2-amino-4-methylsulfanylbutanoicaci

Methionine, amorphousMethionine DL-DL-2-Amino-4-(methylthio)-butyric acidDTXSID9020821NSC-924173JWT2K6T3DTXCID50821CHEBI:16811

データベース識別子

CAS: 26062-47-5、33807-07-7、348-67-4、59-51-8、63-68-3
PubChem CID: 876
DTXSID: DTXSID9020821
ChEMBL: CHEMBL274119
ChEBI: CHEBI:16811
UNII: 73JWT2K6T3
EC Number: 200-432-1
Nikkaji: J1.286F

物性

構造計算による物性

XLogP: -1.9
極性表面積: 88.6 Å²
水素結合供与体数: 2
水素結合受容体数: 4
回転可能結合数: 4
重原子数: 9
形式電荷: 0
複雑度: 97

実験および物理化学的性質

DensityRelative density (water = 1): 1.3

Solubility · 4 件

32.7 mg/mL at 25 °C

Solubility in water, g/100ml at 20 °C: 4.8

Soluble in water; Insoluble in ether

Soluble (in ethanol)

Boiling Point300.00 to 301.00 °C. @ 760.00 mm Hg

Decomposition281 °C

Melting Point281 °C

Physical Description · 4 件

Solid; [Merck Index] Colorless or white solid; [ICSC] White powder; [Sigma-Aldrich MSDS]

Solid

COLOURLESS CRYSTALS OR WHITE POWDER.

White crystalline platelets or powder; Characteristic aroma

物理化学的性質

貯蔵温度: -20 °C · -20°C

安全と法規制

GHS分類

GHS Classification · 3 件

This chemical does not meet GHS hazard criteria for 99% (197 of 199) of all reports.

Not Classified；Reported as not meeting GHS hazard criteria by 197 of 199 companies (only 1% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 199 reports by companies from 4 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 197 of 199 reports by companies.；There are 2 notifications provided by 2 of 199 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory Information · 4 件

Chemical: DL-Methionine

Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)

Methionine is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Methionine are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Methionine: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - DL-Methionine: Human health tier I assessment；IMAP assessments - DL-Methionine: Environment tier I assessment

Fire HazardsGives off irritating or toxic fumes (or gases) in a fire.

Hazards Summary · 1 件

Causes pigmented or nucleated red blood cells, changes in leukocyte counts, and changes in liver, bladder, and spleen weights in repeated-dose oral studies of rats; [RTECS] No listed effects of short-term or long-term exposure; [ICSC] Safe when used as a flavoring agent in food; [JECFA] May cause irritation; [Sigma-Aldrich MSDS]

EPA Safer ChemicalChemical: DL-Methionine； Green circle - The chemical has been verified to be of low concern based on experimental and modeled data.

Chemical DangersDecomposes on heating. This produces toxic fumes of sulfur oxides and nitrous oxides.

安全と保護具

Fire FightingUse water spray, powder, foam, carbon dioxide.

First Aid Measures · 4 件

Fresh air, rest.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth.

Safe StorageSeparated from strong oxidants. Well closed.

Spillage DisposalSweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.

Eye PreventionWear safety spectacles.

Ingestion PreventionDo not eat, drink, or smoke during work.

毒性情報

Exposure RoutesThe substance can be absorbed into the body by ingestion.

法規制情報

Regulatory Information · 4 件

Chemical: DL-Methionine

Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)

Methionine: Does not have an individual approval but may be used under an appropriate group standard

化学と産業

薬理情報

Cellular LocationsCytoplasm；Extracellular

用途と製造

UsesAn essential amino acid; Used therapeutically as an antidote for acetaminophen poisoning and a urinary acidifier; [Merck Index] Used as a flavoring agent and nutritional supplement; [FDA]

U.S. Production2021: 246,400 lb

Industry UsesNot Known or Reasonably Ascertainable

Use Classification · 5 件

EPA Safer Chemical Functional Use Classes -> Enzymes and Enzyme Stabilizers

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavoring Agents -> JECFA Flavorings Index

Cosmetics -> Antistatic; Hair conditioning; Skin conditioning

General Manufacturing Information · 2 件

Not Known or Reasonably Ascertainable

Methionine: ACTIVE