(+-)-Methionine → 4-(1,2-Oxazol-4-yl)phenol

HRID 49401

反応式

HRID 49401 の反応式
NC(C(O)=O)CCSC.C[O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:19]=[N:20][O:21][CH:22]=2)=[CH:14][CH:13]=1.CS(O)(=O)=O>>[O:21]1[CH:22]=[C:18]([C:15]2[CH:14]=[CH:13][C:12]([OH:11])=[CH:17][CH:16]=2)[CH:19]=[N:20]1

参加物

4

反応物 3

HCID 876(+-)-MethionineHCID 6395Methanesulfonic AcidHCID 185236724-(4-Methoxyphenyl)-1,2-oxazole

生成物 1

HCID 185236244-(1,2-Oxazol-4-yl)phenol収率 68.2%

反応条件

温度
70 °C

実験手順

To a round-bottomed flask was added D,L-methionine (1.30 g, 8.73 mmol), 4-(4-methoxy-phenyl)-isoxazole (1.02 g, 5.82 mmol), and methanesulfonic acid (24 ml). The resulting solution was heated to about 70° C. for about eighteen hours, and was then allowed to cool to room temperature and poured onto ice water. The mixture was adjusted to about pH 4, and the heterogenous mixture was filtered. The solid was washed with water and then dried to yield the title compound as an off-white solid (640 mg, 68% yield). LRMS ([M−H]−)=160.0.

後処理

  1. temperatureto cool to room temperature
  2. additionpoured onto ice water
  3. filtrationthe heterogenous mixture was filtered
  4. washThe solid was washed with water
  5. customdried

出典と根拠

ORDレコード
ord-65563c80684040c5aa909fa93bd0af8f
出典データセット
uspto-grants-2004_03
特許番号
US06706743B2

関連ノート

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