1,2-プロパンジオン

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

RECOMMENDED RESPIRATOR: When working with this chemical, wear a NIOSH-approved full face chemical cartridge respirator equipped with the appropriate organic vapor cartridges. If that is not available, a half face respirator similarly equipped plus airtight goggles can be substituted. However, please note that half face respirators provide a substantially lower level of protection than do full face respirators. (NTP, 1992)

In this in vitro study, ... the effect of MG on the structure and function of ceruloplasmin (CP) a serum oxidase carrier of copper ions in the human /was investigated/. When ceruloplasmin (CP) was incubated with methylglyoxal (MG), the protein showed increased electrophoretic mobility which represented the aggregates at a high concentration of MG (100 mM). ... It is suggested that oxidative damage of CP by MG may induce perturbations of the copper transport system and subsequently lead to harmful intracellular condition.

The effect of methylglyoxal alone and in combination with creatine and ascorbic acid on cancer-bearing animals had been investigated by measuring the increase in life span and tumor cell growth inhibition. The results indicated that anticancer effect of methylglyoxal was significantly augmented by ascorbic acid and further augmented by ascorbic acid and creatine. Nearly 80% of the animals treated with methylglyoxal plus ascorbic acid plus creatine were completely cured and devoid of any malignant cells within the peritoneal cavity.

... Methylglyoxal (MG) and D-lactate (DL) were measured by high-performance liquid chromatography in plasma from 57 subjects with type 2 diabetes. Of these subjects, 27 were treated with diet, sulfonylureas, or insulin (nonmetformin), and 30 were treated with metformin; 28 normal control subjects were also studied. Glycemic control was determined by HbA1c. MG was significantly elevated in diabetic subjects versus the normal control subjects (189.3 + 38.7 vs. 123.0 + 37 nmol/L, p = 0.0001). MG levels were significantly reduced by high-dosage (1,500-2,500 mg/d) metformin (158.4 + 44.2 nmol/L) compared with nonmetformin (189.3 + 38.7 nmol/L, p = 0.03) or low-dosage (< or = 1,000 mg/day) metformin (210.98 + 51.0 nmol/L, p = 0.001), even though the groups had similar glycemic control. ... MG correlated with rising HbA1c levels (R = 0.4, p = 0.03, slope = 13.2) in the nonmetformin subjects but showed no increase with worsening glycemic control in the high-dosage metformin group (R = 0.0004, p = 0.99, slope = 0.02).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that methyl glyoxal is expected to have very high mobility in soil(SRC). Volatilization of methyl glyoxal from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 2.70X10-7 atm-cu m/mole(3). Methyl glyoxal is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 27 mm Hg(SRC), determined from a fragment constant method(4). Biodegradation data were not available(SRC, 2007).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that methyl glyoxal is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 2.70X10-7 atm-cu m/mole(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow of -1.50(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data were not available(SRC, 2007).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that methyl glyoxal is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 2.70X10-7 atm-cu m/mole(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow of -1.50(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data were not available(SRC, 2007).

Methyl glyoxal was identified as a coffee aroma constituent at a concentration range of 4.0 nmol to 0.4 mmol(1). The mean concentrations of methyl glyoxal in home-brew and instant coffee are 152 and 114 ug/g, respectively(1). The compound has been detected in autoxidised edible oils (sesame, safflower and sardine oil) at concentrations of 2.5, 2.0 and 7.0 ug/g, respectively, following 30 hrs of heating(2). It was identified as a beef volatile and as a component of beef flavor(3).

Methyl glyoxal gas-phase concentration in medium-duty diesel truck exhaust was 1,700 ug/km(1); from gasoline-powered motor vehicle tailpipe emissions, 50 and 10,000 ug/km in catalyst and non-catalyst equipped vehicles, respectively(2). The compound was identified in a study of light- and heavy-duty vehicle exhaust was measured at the Tuscarora Mountain Tunnel, PA in May 1999; concentrations were 0.167 and 0.289 ug/cu m at the tunnel inlet and outlet, respectively, resulting in an emission factor of 0.23 mg/km(3). The concentration from meat charbroiling was 334,000 ug/kg meat cooked(4). Methyl glyoxal gas-phase effluent concentration resulting from fireplace combustion of wood was 943, 321 and 520 mg/kg wood burned using pine, oak and eucalyptus, respectively(5).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of methyl glyoxal can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that methyl glyoxal is expected to have very high mobility in soil.

URBAN/SUBURBAN: Methyl glyoxal was detected at concentrations of 24, 67, 40 and 39 ng/cu m in aerosol samples collected on February 24-25, February 25-26, July 22-23, and July 23, 1992, respectively, in Tokyo Japan(1). The average ambient concentration in Rio de Janeiro, Brazil, measured from May to November, 2000 at a downtown location during morning vehicle commute, was 1.041 ug/cu m(2).

RURAL/REMOTE: Arctic aerosol samples from Alert, Canada, measured in 1987-1988 showed a methyl glyoxal concentration range of <0.003 to 0.59 ng/cu m(1).

SOURCE DOMINATED: Methyl glyoxal mean concentration in the San Francisco Bay Bridge toll plaza sampled during rush hour traffic April 23 and 24, 2001 was 0.056 ug/cu m, with an estimated range of 0.055 to 0.76 ug/cu m(1). The level in the Los Angeles Van Nuys Tunnel, CA, September 21, 1993 was approximately 10 mg/L (0% weight percentage in gasoline)(2).

/SURVEILLANCE/ ... Methylglyoxal (MG) and D-lactate (DL) were measured by high-performance liquid chromatography in plasma from 57 subjects with type 2 diabetes. Of these subjects, 27 were treated with diet, sulfonylureas, or insulin (nonmetformin), and 30 seconds were treated with metformin; 28 normal control subjects were also studied. Glycemic control was determined by HbA1c. MG was significantly elevated in diabetic subjects versus the normal control subjects (189.3 + 38.7 vs. 123.0 + 37 nmol/L, p = 0.0001). MG levels were significantly reduced by high-dosage (1,500-2,500 mg/d) metformin (158.4 + 44.2 nmol/L) compared with nonmetformin (189.3 + 38.7 nmol/L, p = 0.03) or low-dosage (< or = 1,000 mg/day) metformin (210.98 + 51.0 nmol/L, p = 0.001), even though the groups had similar glycemic control. ... MG correlated with rising HbA1c levels (R = 0.4, p = 0.03, slope = 13.2) in the nonmetformin subjects but showed no increase with worsening glycemic control in the high-dosage metformin group (R = 0.0004, p = 0.99, slope = 0.02)

/SURVEILLANCE/ ... A cross-sectional study was undertaken to determine whether methylglyoxal (MG) accumulates in the gingival crevicular fluid (GCF) of chronic periodontitis patients. GCF samples were collected for 30 seconds each from three teeth with pocket depths greater than 3 mm (DD sites), from 14 chronic periodontitis patients. Control samples were taken from three healthy sites (DH sites) in the same patients, as well as from seven subjects who were periodontally healthy (HH sites). ... Mean pocket depths were 5.7 +/- 0.7, 2.7 +/- 0.6 and 2.7 +/- 0.5 mm (mean +/- SD) for the DD, DH and HH sites, respectively. Mean MG levels were found to be 208.7 +/- 241.7 and 142.9 +/- 235.7 pmol/site in the GCF from DD and DH sites, respectively (p=0.0023), but only 11.5 +/- 4.4 pmol/site for the HH sites

/SURVEILLANCE/ ... The production of the glycolytic intermediate methylglyoxal (MG) was followed up in 7 diabetic patients treated for ketoacidosis during pretreatment and recovery phase. Blood samples for methylglyoxal analysis were collected upon patient arrival in emergency department (0 hr), and during ketoacidosis treatment between 12-24 hr and at 168 hr. The study also included 10 normoglycaemic healthy volunteers and 31 type 1 diabetic patients (control diabetes group). The methylglyoxal assay, based on methylglyoxal derivation with 1,2-diamino-4,5-dimethoxybenzene (DDB), was performed by HPLC, only assessing the level of free methylglyoxal. The baseline level of methylglyoxal recorded in normoglycemic healthy controls was 338 + 62 nmol/L versus 374 + 89 nmol/L in control diabetes group (p = 0.0407). A consistent feature of diabetic ketoacidosis before and during treatment was striking elevation of methylglyoxal as compared with control diabetes group (median test chi(2) = 14.6, df = 3, p = 0.0021). Friedman's ANOVA indicated differences (p = 0.04) among the three sampling times with a peak value (601 +/- 95 nmol/L) at 12-24 hr following therapy initiation. However, fasting treatment values at 168 hr were still significantly higher than the mean fasting methylglyoxal level in control diabetes group (p = 0.008). The study indicated that diabetic ketoacidosis results in an increase in methylglyoxal level.

Methylglyoxal

Group 3: Not classifiable as to its carcinogenicity to humans

Volume 51: (1991) Coffee, Tea, Mate, Methylxanthines and Methylglyoxal

1991

1990

An estimated BCF of 3 was calculated in fish for methyl glyoxal(SRC), using an estimated log Kow of -1.50(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Henry's Law constant for methyl glyoxal is 2.70X10-7 atm-cu m/mole(1). This Henry's Law constant indicates that methyl glyoxal is expected to be essentially nonvolatile from water surfaces(2). Methyl glyoxal's Henry's Law constant indicates that volatilization from moist soil surfaces may not occur(SRC). Methyl glyoxal is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 27 mm Hg(SRC), determined from a fragment constant method(3).

Pyruvaldehyde is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and 2) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.

Used in organic synthesis, as a flavoring agent, and in tanning leather; [ChemIDplus]

Leather Tanning and Processing [Category: Industry]

Organic synthesis, as of complex chemical compounds such as pyrethrins, tanning leather, flavoring.

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavoring Agents -> JECFA Flavorings Index

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes