Methylglyoxal → HCID 178430963、化合物
反応式
[NH2:1][CH2:2][C:3]([NH:5][OH:6])=[O:4].CO.[CH3:9][C:10]([CH:12]=O)=O.[OH-].[Na+]>O>[CH3:12][C:10]1[CH:9]=[N+:5]([O-:6])[C:3]([OH:4])=[CH:2][N:1]=1参加物
6
反応条件
- 温度
- 5 °C
実験手順
100 mmol (9 g) glycine hydroxamic acid were cooled to −25° C. in 200 ml water and methanol each, 100 mmol (15.4 ml 40% solution) methylglyoxal were added dropwise and subsequently the pH was adjusted to approximately pH 11 with 10 ml 30% NaOH. Heating up to 5° C. was carried out in 2 h and concentrated under vacuum to half of the solvent volume. A pH 3 was adjusted with 20% HCl, precipitated solid was filtered off and dried. 7.28 g (52% yield) of the title compound were obtained.
後処理
- concentrationconcentrated under vacuum to half of the solvent volume
- customprecipitated solid
- filtrationwas filtered off
- customdried
出典と根拠
- ORDレコード
- ord-4d7c9ee2a2db4964a663905b500c8598
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09439910B2
反応ノート
読み込み中…