亜硫酸O-(2-クロロエチル)O-[2-[4-(1,1-ジメチルエチル)フェノキシ]-1-メチルエチル]

亜硫酸O-(2-クロロエチル)O-[2-[4-(1,1-ジメチルエチル)フェノキシ]-1-メチルエチル] · アラマイト · ナイアガラマイト · アラミット · アラシド · オルト-ミット · オルソ-マイト · アラトロン

識別子と物理属性

CAS No.	140-57-8
分子式	C15H23ClO4S
平均分子量	334.9 g/mol
単同位体質量	334.1005579 g/mol
SMILES	CC(COc1ccc(C(C)(C)C)cc1)OS(=O)OCCCl
InChIKey	YKFRAOGHWKADFJ-UHFFFAOYSA-N
PubChem CID	8809
ChEMBL	CHEMBL1903447
ChEBI	CHEBI:82151
EC No.	690-073-0
DTXSID	DTXSID3020097
現地名	亜硫酸O-(2-クロロエチル)O-[2-[4-(1,1-ジメチルエチル)フェノキシ]-1-メチルエチル]

化学・物理的性質

XLogP	4.6
極性表面積	64
水素結合供与体数	0
水素結合受容体数	5
回転可能結合数	9
重原子数	21
形式電荷	0
複雑度	311
物質分類	Carcinogens
SpringerMaterials Properties	Optical coefficient
農薬	Pesticide -> EPA IRISInsecticidesActive substance -> EU Pesticides database: Not approvedPesticides -> Other Insecticides
密度	1.143 at 20 °C/20 °CDENSITY: 1.145-1.162 /TECHNICAL PRODUCT/1.195
Color/Form	Colorless liquidClear light-colored oil
溶解度	Practically insol in watermiscible with many organic solventssolubility in petroleum oils decr rapidly with decr temperatures> 10% in ethanol> 10% in benzene> 10% in acetoneFor more Solubility (Complete) data for ARAMITE (7 total), please visit the HSDB record page.クロロホルム（微量）、メタノール（微量）
Corrosivity	Noncorrosive
沸点	175 °C at 0.1 mm HgBP: 195 °C at 2 mm Hgbp0.1 175°bp7.0 200-210°
Decomposition	WHEN HEATED TO DECOMPOSITION, EMITS HIGHLY TOXIC FUMES OF /HYDROGEN CHLORIDE AND SULFUR OXIDES/.
融点	-31.7 °C-31.7°
蒸気圧	0.00000022 [mmHg]
Physical Description	Colorless liquidTechnical product is dark amber liquid[HDSB]
屈折率	nD20 1.5100 to 1.5118nD27 1.5075
貯蔵条件	2-8°C
外観・状態	油
色	無色～淡褐色
ヘンリー定数	5.2×101 mol/(m3Pa) at 25℃, HSDB (2015)
安定性	Hygroscopic
主な用途	環境
InChI	1S/C15H23ClO4S/c1-12(20-21(17)19-10-9-16)11-18-14-7-5-13(6-8-14)15(2,3)4/h5-8,12H,9-11H2,1-4H3
InChIKey	YKFRAOGHWKADFJ-UHFFFAOYSA-N
EPAの化学物質情報	Aramite (140-57-8)

化学的特性

Aramite is a heavy, dark-amber liquid.

安全性と法規制

GHS 分類	DangerH315 (92.9%): Causes skin irritation [Warning Skin corrosion/irritation]P203, P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P318, P321, P332+P317, P337+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 42 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H351: Suspected of causing cancer [Warning Carcinogenicity]
規制情報	Hazard Traits - CarcinogenicityThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
有害性の概要	A skin and eye irritantCarcinogenic in animal experiments[HSDB]
Special Reports	National Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Aramite (140-57-8) is delisted as reasonably anticipated to be a human carcinogen.[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/append/appb.pdf]
FIFRA 要件	This product was voluntarily cancelled on the basis of oncogenicity according to US EPA in a notice dated April 12, 1977.This rule revokes the tolerances established for residues of 20 pesticide chemicals /including aramite/ in or on certain raw agricultural commodities. This regulatory action is being taken by EPA to revoke tolerances for those pesticides which have no registered food uses or if they were registered the registrations were subsequently cancelled. 40 CFR Part 180 is amended: Section 180.107 is removed.
Hazard Classes and Categories	Skin Irrit. 2 (92.9%)Carcinogenicity - Category 2Acute toxicity (Oral) - Category 5Carcinogens
Skin, Eye, and Respiratory Irritations	Irritant to eyes & skin ... .

用途

説明

Aramite is a synthetic chlorinated hydrocarbon with molecular weight of 334.87 and density of 1.143 at 20°C. It is a clear, light-colored oil with melting point of 37.3 C and boiling point of 175 °C at 0.1 mm Hg. The technical grade aramite is a dark amber liquid. Aramite is soluble at 0.000 1% (practically insoluble) in water but is miscible in many organic solvents. It was sold as mixture in organic solvents at different strengths for further dilution and use. Aramite was used as a pesticide (acaricide) to control mites in plants and animals. Aramite was initially introduced to market around 1950. It was mostly used between 1950 and 1954 in greenhouses in the United States. Its manufacture and use were voluntarily discontinued due to its carcinogenic potential according to a US Environmental Protection Agency (EPA) notice dated 12 April 1977. However, there are reports of bans of aramite use in a few European countries, in 1987 (Lithuania), 1996 (Poland), and 1999 (Estonia). There is no information on the production, import, registration, marketing, stockpiling, and use of aramite in Russia. Occupational exposure through dermal contact and inhalation was possible during its use.

使用

Aramite was formerly used in control of mites (miticide) in citrus fruits, vegetables, and animals. Active mite stage was most sensitive to aramite toxicity. The death in mites was due to paralysis and disorganized movements of appendages, leading to detachment from the plant. Insects and mites other than Tetracychidae are not as sensitive to aramite. Mites exposed in the field to up to 21 applications were not found to develop resistance in mites, unlike other organochlorines where insects develop resistance rapidly. Aramite is rendered inactive when mixed with lime and other alkaline materials. Aramite was used in combination of other pesticides to control a wide range of mite species.

一般的な説明

Aramite is a carcinogenic acaricide, widely used against six spotted mite, European red mite and others affecting crops.