N-(2-ヒドロキシエチル)ラウリンアミド

Lauric acid monoethanolamide

HCID 8899CAS 142-78-9

基本情報

標準SMILES
CCCCCCCCCCCC(=O)NCCO
InChIKey
QZXSMBBFBXPQHI-UHFFFAOYSA-N
分子式
C14H29NO2
平均分子量
243.39 g/mol
単同位体質量
243.21982917

名称と識別子

優先名称
Lauric acid monoethanolamide
IUPAC
N-(2-hydroxyethyl)dodecanamide
現地名
N-(2-ヒドロキシエチル)ラウリンアミド
英語名
Lauric acid monoethanolamide
分子式
C14H29NO2
分子量
243.39

名称と別名

N-(2-HYDROXYETHYL)DODECANAMIDE142-78-9Lauric acid monoethanolamideN-LauroylethanolamineLaurylethanolamideCopramylAmisol LDEComperlan LMLauridit LMVistalanLauroyl monoethanolamideUltrapole H
名称をさらに表示
コプラミルN-(2-ヒドロキシエチル)ラウリンアミドコムペルランLMN-(2-ヒドロキシエチル)ラウリン酸アミドアミソールLMEココモノエタノールアミドN-ラウロイルエタノールアミドN-ラウロイルエタノールアミンN-(2-ヒドロキシエチル)ドデカンアミドラウラミドMEAラウリン酸モノエタノールアミドLauramide MEACocomonoethanolamidecoconut monoethanolamideamisolldeamisollmeNinol LMProlamidcm
Cyclomide LMRolamid CMStabilor CMHCrillon LMEAmisol LMELauric ethylolamideLauric acid ethanolamideDodecanamide, N-(2-hydroxyethyl)-

データベース識別子

CAS
142-78-9
PubChem CID
8899
DTXSID
DTXSID5025493
ChEMBL
CHEMBL246914
ChEBI
CHEBI:85263
UNII
098P2IGT76
EC Number
205-560-1
Nikkaji
J103.087F

物性

構造計算による物性

XLogP
4
極性表面積
49.3 Ų
水素結合供与体数
2
水素結合受容体数
2
回転可能結合数
12
重原子数
17

実験および物理化学的性質

Solubilityless than 1 mg/mL at 68 °F (NTP, 1992)
Vapor Pressure0.00000001 [mmHg]
Physical Description · 3 件

Lauryl ethanolamide is a cream-colored flakes. (NTP, 1992)

Liquid; Other Solid

Cream-colored solid; [CAMEO]

物理化学的性質

融点
88 · 88-89℃
沸点
410.7 · 410.7±28.0 °C(Predicted)
比重(密度)
0.925 · 0.925
蒸気圧
0.009 Pa · 0.009Pa at 25℃
貯蔵温度
Sealed in dry,Room Temperature
酸解離定数(Pka)
14.49 · 14.49±0.10(Predicted)

安全と法規制

GHS分類

GHS Classification · 5 件

Danger

H318 (76.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation];H319 (23.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H411 (23.3%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P264+P265, P273, P280, P305+P351+P338, P305+P354+P338, P317, P337+P317, P391, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 649 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory Information · 4 件

Chemical: Dodecanamide, N-(2-hydroxyethyl)-

Dodecanamide, N-(2-hydroxyethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Dodecanamide, N-(2-hydroxyethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 23-04-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/25660;Status: Active Update: 27-12-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/21833

Laurylethanolamide: Does not have an individual approval but may be used under an appropriate group standard

Fire HazardsFlash point data for this chemical are not available, but it is probably combustible. (NTP, 1992)
Hazards SummaryEmergency treatment: Detergents and soaps-anionic and nonionic; [HSDB] Highly irritating to eye--risk of serious damage; [IUCLID] May cause irritation; [MSDSonline]
Reactive GroupAlcohols and Polyols;Amides and Imides
Reactivity Profile · 1 件

LAURYL ETHANOLAMIDE is a very weak base. Reacts with azo and diazo compounds to generate toxic gases. Flammable gases are formed with strong reducing agents. Reacts with dehydrating agents such as P2O5 or SOCl2. Combustion generates mixed oxides of nitrogen.

Air and Water ReactionsInsoluble in water.

安全と保護具

Fire FightingFires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 件

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.;SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.;INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.;INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Nonfire Spill Response · 1 件

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.;STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

Personal Protective Equipment (PPE) · 1 件

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

毒性情報

Toxicity Summary · 2 件

The CIR Expert Panel concluded that the ethanolamides listed subsequently are safe in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating. The Expert Panel cautioned that these ingredients should not be used in cosmetic products in which N-nitroso compounds may be formed...Lauramide MEA...

Safe for use in cosmetics, with qualifications

Non-Human Toxicity Excerpts · 1 件

Lauryl ethanolamide (LE) was tested for mutagenicity in the Salmonella/microsome preincubation assay using a protocol approved by the National Toxicology Program. LE was tested over a wide range of doses (0, 3.0, 10, 33, 100, 333, 1000, and 3333 ug/plate) in four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) in the presence and absence of Aroclor-induced rat or hamster liver S9. LE was negative in these tests and the highest ineffective dose level tested (not causing the formation of a precipitate) in any Salmonella tester strain was 100 ug/plate.

法規制情報

Regulatory Information · 4 件

Chemical: Dodecanamide, N-(2-hydroxyethyl)-

Dodecanamide, N-(2-hydroxyethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Dodecanamide, N-(2-hydroxyethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 23-04-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/25660;Status: Active Update: 27-12-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/21833

Laurylethanolamide: Does not have an individual approval but may be used under an appropriate group standard

安全データ

tsca
TSCA listed
有毒物質データの
142-78-9(Hazardous Substances Data)

化学と産業

用途と製造

Uses · 2 件

CIR ingredient: Lauramide MEA

Ultrapoles is the trademark for several alkanolamine condensates that are surface-active agents; Ultrapoles are used as detergents and in detergents, wetting and foaming agents, foam stabilizers, cosmetic preparations, emollients, and thickening agents; [HSDB]

U.S. Production2023: 1,000,000 - <2,500,000 lb;2022: 2,500,000 - <4,000,000 lb;2021: 1,000,000 - <2,500,000 lb;2020: 2,500,000 - <4,000,000 lb
Consumer UsesSurfactant (surface active agent);Thickening agent
Industry UsesSurfactant (surface active agent);Thickening agent
Household ProductsInformation on 27 consumer products that contain Lauramide MEA in the following categories is provided:;• Inside the Home;• Personal Care;• Pet Care
Use ClassificationCosmetics -> Viscosity controlling; Antistatic; Surfactant; Foam boosting

応用分野

一般的な説明Cream-colored flakes.

上流・下流製品情報

サプライヤー50 社

江西益众化工有限公司15307925109 15350027073 · [email protected]
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
湖北万得化工有限公司15377098680 15377098680 · [email protected]
毕佳索(上海毕得医药科技股份有限公司)400-6005915 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]

補足説明

定義本品は、ラウリン酸(*)のモノエタノールアミドであり、次の化学式で表される。参照表示名称:ラウリン酸

定義ChEBI: An N-(long-chain-acyl)ethanolamine resulting from the formal condensation of the carboxy group of dodecanoic acid (myristic acid) with the amino group of ethanolamine.

関連反応

4 件

関連ノート

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