Ethanolamine → Lauric acid monoethanolamide

HRID 1659896

反応式

HRID 1659896 の反応式
[CH2:1]([CH2:3][NH2:4])[OH:2].[C:5](O)(=[O:17])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]>C1(C)C=CC=CC=1>[OH:2][CH2:1][CH2:3][NH:4][C:5](=[O:17])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

参加物

4

反応物 2

HCID 700EthanolamineHCID 3893Lauric Acid

生成物 1

HCID 8899Lauric acid monoethanolamide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
140 °C

実験手順

To a solution of 24 g (0.4 mole) ethanolamine in 100 ml toluene was added 40 g (0.2) lauric acid at 50° C. The mixture was refluxed for 6 hours. Toluene was gradually removed to increase the final pot temperature to 140° C. The distillate was collected in a Stark & Dean trap. The toluene was removed by vacuum stripping and the residue was crystallized from n-hexane. The title compound (44 g) thus obtained melted at 80°-84° C.

後処理

  1. temperatureThe mixture was refluxed for 6 hours
  2. customToluene was gradually removed
  3. distillationThe distillate was collected in a Stark & Dean trap
  4. customThe toluene was removed by vacuum stripping
  5. customthe residue was crystallized from n-hexane

出典と根拠

ORDレコード
ord-891d879642f2463097f63866a9287d86
出典データセット
uspto-grants-1981_12
特許番号
US04305868

関連ノート

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