メタクリル酸ドデシル

0.868 at 77 °F (USCG, 1999) - Less dense than water; will float

0.87 at 77 °F (approx) (USCG, 1999) - Less dense than water; will float

0.868 @ 20 °C

The commercial material is a mixture containing both lower and higher fatty derivatives; boiling range: 272-344 °C; bulk density: 0.868 g/ml

0.868 @ 20°C

greater than 230 °F (USCG, 1999)

132 °C (Cleveland open cup)

126 °C (closed cup)

-8 °F (USCG, 1999)

-20 °C

Molecular weight: 262; melting point: -22 °C; /Made from a mixture of higher alcohols, predominately C-12/

Methyl methacrylate, and in general the methacrylic esters, polymerize much less readily than the corresponding ordinary acrylates. None the less, they are stabilized by adding hydroquinone or pyrogallol, particularly in the presence of metallic copper. /methacrylates/

0.00118 [mmHg]

0.0012 mm Hg @ 25 °C /Estimated/

0.0012 [mm Hg] @20 °C

Dodecyl methacrylate is a liquid. Floats on water. (USCG, 1999)

Dodecyl/pentadecyl methacrylate is a colorless liquid. Less dense than water and insoluble in water. A mixture of esters of methacrylic acid. (USCG, 1999)

Liquid

Liquid; [CAMEO] Clear colorless liquid; [MSDSonline]

Warning

H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P271, P304+P340, P319, P403+P233, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for 5% (66 of 1322) of reports.

Chemical: 2-Propenoic acid, 2-methyl-, dodecyl ester

2-Propenoic acid, 2-methyl-, dodecyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propenoic acid, 2-methyl-, dodecyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 13-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14902

Dodecyl methacrylate: Does not have an individual approval but may be used under an appropriate group standard

Behavior in Fire: Heat can induce polymerization with rapid release of energy. Sealed containers may rupture explosively. (USCG, 1999)

Behavior in Fire: Heat can induce polymerization with rapid release of energy. Sealed contawiners may rupture explosively. (USCG, 1999)

Inhalation temporarily reduces blood pressure from 5 to 25%, increases respiratory rate, decreases heart rate, and causes some EKG changes. Liquid may cause irritation of eyes and skin. May be harmful if swallowed. (USCG, 1999)

Inhalation temporarily reduces blood pressure from 5 to 25%, increases respiratory rate, decreases heart rate, and causes some EKG changes. Liquid may cause irritation of eyes and skin. May be harmful if swallowed. (USCG, 1999)

A mild skin and eye irritant in rabbits; [HSDB] May polymerize; May irritate skin and eyes; [CAMEO] A skin and eye irritant; [eChemPortal: ERMA] A skin, eye, and respiratory tract irritant; [eChemPortal: ESIS] An irritant; [MSDSonline] See ACRYLIC RESINS (MONOMERS).

Acrylates and Acrylic Acids；Polymerizable Compounds

Acrylates and Acrylic Acids；Polymerizable Compounds

Polymerizable

Polymerizable

DODECYL METHACRYLATE is an acrylate ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Tends to polymerize. Oxidizing and reducing agents may initiate polymerization. Reaction may also occur when heated (USCG, 1999).

DODECYL/PENTADECYL METHACRYLATE reacts with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by interaction with caustic solutions. Flammable hydrogen is generated by mixing with alkali metals and hydrides. Tends to polymerize. Oxidizing and reducing agents may initiate polymerization. Polymerization may also occur when heated (USCG, 1999).

No rapid reaction with air. No rapid reaction with water.

Insoluble in water.

Skin Irrit. 2 (87.6%)；Eye Irrit. 2 (87.6%)；STOT SE 3 (95%)；Aquatic Acute 1 (83.3%)；Aquatic Chronic 1 (84.3%)

Specific target organ toxicity (single exposure) - category 3

Serious eye damage/eye irritation - Category 2B

STOT SE 3

Fire Extinguishing Agents: Foam, CO2 or dry chemical (USCG, 1999)

Fire Extinguishing Agents: Foam, CO2, or dry chemical (USCG, 1999)

INHALATION: Move victim to fresh air. If breathing has stopped, give artificial respiration. If breathing is difficult, give oxygen.；EYES OR SKIN: Flush with running water for at least 15 min; hold eyelids open if neccessary. Wash skin with soap and water.；INGESTION: If victim is conscious, have victim drink milk or water and induce vomiting. If victim is unconscious or having convulsions, do nothing except keep victim warm. (USCG, 1999)

INHALATION: Move victim to fresh air. If breathing has stopped, give artificial respiration. If breathing is difficult, give oxygen.；EYES OR SKIN: Flush with running water for at least 15 minutes; hold eyelids open if necessary. Wash skin with soap and water.；INGESTION: If victim is conscious, have victim drink water or milk and induce vomiting. If victim is unconscious or having convulsions, do nothing except keep victim warm. (USCG, 1999)

Temp during storage must be kept low to minimize formation of peroxides and other oxidation products. ... Storage temp below 30 °C are recommended for the polyfunctional methacrylates. ... The methacrylate monomers should not be stored for longer than one year. Shorter storage times are recommended for the aminomethacrylates, ie, three months, and the polyfunctional methacrylates, ie, six months. Many of these cmpd are sensitive to UV light and should, therefore, be stored in the dark. The methacrylic esters may be stored in mild steel, stainless steel, or aluminum. /Methacrylic acid & derivatives/

To avoid photoinitiation of polymerization, all methacrylates should be stored with minimal exposure to light.

The effectiveness of phenolic inhibitors is dependent on the presence of oxygen and the monomers must be stored under air rather than an inert atmosphere. Temp must be kept low to minimize formation of peroxides and other products. Moisture may cause rust-initiated polymerization. /Acrylic acid & derivatives/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

... Hazard is the generation of considerable exothermic heat in some of the reactions, so that high pressures & temp may develop. This danger ... should be borne in mind when designing plant. Awareness of the dangers and of good engineering design are essential to safety. Employees should be instructed about the necessity of cleansing the skin if it is contaminated by materials which are irritants or skin-absorbed. With careful design, however, and complete enclosure of those processes where toxic chemicals or intermediates occur, dangerous exposures can be avoided. /Acrylic acid & derivatives/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

72 [mg/m3]

790 [mg/m3]

4800 [mg/m3]

Wear self-contained positive pressure breathing apparatus and full protective clothing. (USCG, 1999)

Wear self-contained positive pressure breathing apparatus and full protective clothing. (USCG, 1999)

Suitable protective clothing and self-contained respiratory protective apparatus should be available for use of those who may have to rescue persons overcome by fumes. /acrylic acid and derivatives/

Based on available data, the CIR Expert Panel concluded that ... Lauryl Methacrylate is safe as used in nail enhancement products when skin contact is avoided. Products containing these ingredients should be accompanied with directions to avoid skin contact, because of the sensitizing potential of Methacrylates.

Safe for use in cosmetics, with qualifications

/LABORATORY ANIMALS: Acute Exposure/ Methacrylate ester monomer and methacrylic acid decreased the heart rate and force of contraction of the isolated, perfused rabbit heart when added to the perfusing liquid at concentrations of 1:1000, 1:10,000 or 1:100,000 (vol/vol), and most of the cmpd decreased the coronary flow rate. Methacrylic acid, methyl methacrylate, ethyl methacrylate, and dimethylaminoethyl methacrylate produced an irreversible effect on the isolated heart at all 3 concentrations, while 1,3-butylene dimethacrylate, 2-ethylhexyl methacrylate, isodecyl methacrylate, and lauryl methacrylate produced only a reversible effect at all 3 concentrations.

/LABORATORY ANIMALS: Acute Exposure/ Methacrylic acid administration iv increased respiratory rate, decreased heart rate, and produced electrocardiogram changes in anesthetized dogs. Methacrylic acid, methyl, n-propyl, n-butyl, isobutyl, and hydroxyethyl methacrylates produced a biphasic response, an abrupt fall in blood pressure followed by a secondary rise. 2-ethylhexyl, isodecyl, lauryl, and tert-butylaminoethyl methacrylates produced only a hypotensive effect. Dimethylaminoethylmethacrylate produced only a hypertensive effect.

/LABORATORY ANIMALS: Acute Exposure/ ...To determine the effect of side-chain length on sensitizing potential, we examined 11 derivatives with linear side chains from C1 to C18 in an experimental sensitization test in guinea pigs. The results showed an increase in the sensitizing potential with increasing length of the alkyl side chain from C1 to C12. The C12 derivative, lauryl methacrylate, showed the strongest sensitizing potential.

/LABORATORY ANIMALS: Acute Exposure/ A 500 mg dose over a 24 hr period caused mild irritation to skin and eyes of rabbits. /from table/

For more Non-Human Toxicity Excerpts (Complete) data for N-DODECYL METHACRYLATE (6 total), please visit the HSDB record page.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

LD50 Rat oral >5.0 g/kg

LD50 Rabbit percutaneous >3.0 g/kg

LD50 Rat ip 21.6 g/kg

LD50 Mouse oral >87,250 mg/kg

For more Non-Human Toxicity Values (Complete) data for N-DODECYL METHACRYLATE (6 total), please visit the HSDB record page.

Chemical: 2-Propenoic acid, 2-methyl-, dodecyl ester

2-Propenoic acid, 2-methyl-, dodecyl ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propenoic acid, 2-methyl-, dodecyl ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 13-01-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14902

Dodecyl methacrylate: Does not have an individual approval but may be used under an appropriate group standard

Small quantities of methacrylates may readily be metabolized by saponification into the alcohol and methacrylic acid. The latter may form an acetyl-coenzyme A derivative, which then enters the normal lipid metabolism. /Methacrylates/

Acrylates and methacrylates are detoxified predominantly via conjugation with glutathione via the Michael addition reaction or glutathione-S-transferase. They are also likely to be hydrolyzed via carboxylesterases. The lower molecular weight esters are rapidly metabolized and eliminated, therefore, will not likely cause cumulative toxicity. /Methacrylates/

CIR ingredient: Lauryl Methacrylate

Used as monomer (plastics, molding powders, solvent coatings, adhesives, oil additives, viscosity index improvers, and pour-point depressants for distillate fuels), softener for lacquers, and industrial deodorant for methyl sulfide odors; Used in emulsions (textile, leather, and paper finishing) and insecticides (delay volatilization); [HSDB]

Pulp and Paper Processing [Category: Industry]；Painting (Pigments, Binders, and Biocides) [Category: Paint]；Farming (Pesticides) [Category: Industry]；Plastic Composites Manufacturing [Category: Industry]；Leather Tanning and Processing [Category: Industry]；Textiles (Printing, Dyeing, or Finishing) [Category: Industry]

For N-dodecyl methacrylate (USEPA/OPP Pesticide Code: 053101) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Polymerizable monomer for plastics, molding powders, solvent coatings, adhesives, oil additives; emulsions for textile, leather, and paper finishing.

As a deodorant to mask methyl sulfide odors in industry.

The methacrylates can be synthesized by catalytic oxidation of isobutylene and subsequent esterification with the appropriate alcohol, or by reacting acetone with hydrocyanic acid and subsequent esterification in sulfuric acid with the appropriate alcohol. /Methacrylic esters/

... Manufactured by direct esterification of methacrylic acid or transesterification of methyl methacrylate.

Fragrance Ingredients

Cosmetics -> Viscosity controlling

All Other Basic Organic Chemical Manufacturing；Other (requires additional information)；Paint and Coating Manufacturing；Plastics Material and Resin Manufacturing；All Other Chemical Product and Preparation Manufacturing；Adhesive Manufacturing；Petroleum Lubricating Oil and Grease Manufacturing；Printing and Related Support Activities

2-Propenoic acid, 2-methyl-, dodecyl ester: ACTIVE

Methyl methacrylate, and in general the methacrylic esters, polymerize much less readily than the corresponding ordinary acrylates. None the less, they are stabilized by adding hydroquinone or pyrogallol, particularly in the presence of metallic copper. /Methacrylates/