D-トリプトファン

D-Tryptophan

HCID 9060CAS 153-94-6

基本情報

標準SMILES
N[C@H](Cc1c[nH]c2ccccc12)C(=O)O
InChIKey
QIVBCDIJIAJPQS-SECBINFHSA-N
分子式
C11H12N2O2
平均分子量
204.22 g/mol
単同位体質量
204.08987762

概要

D(+)-tryptophan is a white solid. (NTP, 1992)

名称と識別子

優先名称
D-Tryptophan
IUPAC
(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid
現地名
D-トリプトファン
英語名
D-Tryptophan
分子式
C11H12N2O2
分子量
204.23

名称と別名

D-Tryptophan153-94-6D(+)-Tryptophan(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid(R)-Tryptophan(+)-TryptophanD-TrytophaneTryptophan, D-D-(+)-TryptophanDTXSID00469897NS97N9H1GEINECS 205-819-9
名称をさらに表示
D-トリプトファン(R)-3-(1H-インドール-3-イル)-2-アミノプロパン酸(-)-トリプトファン(R)-2-アミノ-3-(1H-インドール-3-イル)プロパン酸(αR)-α-アミノ-1H-インドール-3-プロパン酸(-)-D-トリプトファン(R)-α-アミノ-1H-インドール-3-プロパン酸(R)-(+)-2-アミノ-3-(3-インドリル)プロピオン酸D‐トリプトファンD-TRPH-D-TRP-OHLTRD-Trp-OHWVD-TriptophanD-2-AMINO-3-(3-INDOLYL)PROPIONIC ACIDTRP-01
NSC 97942CHEBI:16296NSC-97942DTXCID8026989DTryptophane(R)TryptophanTryptophan, DD(+)Tryptophan

データベース識別子

CAS
153-94-6
PubChem CID
9060
DTXSID
DTXSID0046989
ChEMBL
CHEMBL292303
ChEBI
CHEBI:16296
UNII
7NS97N9H1G
EC Number
205-819-9
Nikkaji
J9.185E

物性

構造計算による物性

XLogP
-1.1
極性表面積
79.1 Ų
水素結合供与体数
3
水素結合受容体数
3
回転可能結合数
3
重原子数
15

実験および物理化学的性質

Chemical ClassesBiological Agents -> Amino Acids and Derivatives
DrugsPharmaceuticals -> Listed in ZINC15
Solubility1 to 5 mg/mL at 75 °F (NTP, 1992)
Melting Point · 3 件

527 to 540 °F (NTP, 1992)

282-85 dec °C

282 - 85 °C

Physical Description · 3 件

D(+)-tryptophan is a white solid. (NTP, 1992)

White solid; [CAMEO] White powder; [Alfa Aesar MSDS]

Solid

Collision Cross Section · 2 件

151.5 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID0046989]

142.6 Ų [M-H]-

物理化学的性質

融点
282 · 282-285 °C (dec.)(lit.)
比旋光度
31.5 · 31.5 º (c=1, H2O 24 ºC)
沸点
342.72 °C · 342.72°C (rough estimate)
比重(密度)
1.1754 · 1.1754 (rough estimate)
屈折率
31 ° · 31 ° (C=1, H2O)
貯蔵温度
Keep in dark place,Inert atmosphere,Room temperature

化学的性質

化学的特性white powder

安全と法規制

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 87.5% (7 of 8) of all reports.

Warning

H315 (12.5%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 8 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory InformationD-Tryptophan: Does not have an individual approval but may be used under an appropriate group standard
Fire HazardsFlash point data are not available for this chemical, but it is probably combustible. (NTP, 1992)
Hazards SummaryCauses altered sleep time (including change in righting reflex), dyspnea, and decreased body temperature in intraperitoneal lethal-dose studies of rats (LD50 = 4,289 mg/kg); [RTECS] May cause irritation; [Alfa Aesar MSDS]
Reactive GroupSalts, Acidic
Reactivity Profile · 1 件

Acidic salts, such as D(+)-TRYPTOPHAN, are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Air and Water ReactionsSlightly soluble in water.

安全と保護具

Fire FightingFires involving this compound should be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 件

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 件

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, you should dampen the solid spill material with alcohol, then transfer the dampened material to a suitable container. Use absorbent paper dampened with alcohol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminate area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Personal Protective Equipment (PPE) · 1 件

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

安全データ

F
8
wgk
3
tsca
TSCA listed
rtecs
YN6129000
hs_code
29339990
risk_code
36/37/38-41-37/38-22

化学と産業

用途と製造

UsesTryptophan is an essential amino acid; [Merck Index] Used as a dietary supplement and for nutrition research; [NTP]
General Manufacturing InformationD-Tryptophan: ACTIVE

応用分野

使用An essential amino acid found in naturally produced pedtides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins.

一般的な説明White solid.

サプライヤー50 社

北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]

補足説明

定義ChEBI: The D-enantiomer of tryptophan.

関連反応

53 件

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