Piperidine-2-methylamine (HCID 90865)

概要

2-Piperidinemethanamine is a member of piperidines.

名称と識別子

優先名称: Piperidine-2-methylamine
IUPAC: piperidin-2-ylmethanamine
現地名: ピペリジン-2-メタンアミン
英語名: 2-PIPERIDYLMETHYLAMINE
分子式: C6H14N2
分子量: 114.19

名称と別名

2-PiperidinemethanaminePiperidine-2-methylamineEINECS 245-371-1EC 245-371-1RefChem:863579245-371-122990-77-82-PIPERIDYLMETHYLAMINE2-(Aminomethyl)piperidinepiperidin-2-ylmethanamine2-Aminomethylpiperidine2-(AMINOMETHYL)-1-PIPERIDINE

名称をさらに表示

2-(アミノメチル)ピペリジンピペリジン-2-メタンアミン2-ピペリジンメタンアミン2-ピペリジルメチルアミン2-(アミノメチル)ピペリジン, 98%1-(ピペリジン-2-イル)メタンアミン2AMPPR2-(Aminomethyl)2-PIPERIDYLMETHYLAMIPiperidine-2-methanamine2-AMINOMETHYL PIPERIDINEFlecainide EP Impurity B

1-(piperidin-2-yl)methanamineMFCD00129011Piperidine, 2-(aminomethyl)-2-Aminomethyl-1-piperidine(RS)-(Piperidin-2-yl)methanamine(piperidin-2-yl)methanamineFlecainide Acetate Imp. B (EP); (RS)-(Piperidin-2-yl)methanamine; Flecainide Acetate Impurity B; Flecainide Impurity B2-piperidylmethanamine

データベース識別子

CAS: 22990-77-8
PubChem CID: 90865
DTXSID: DTXSID80945687
ChEBI: CHEBI:229435
UNII: 9Y4RLA45BH
EC Number: 245-371-1
Nikkaji: J43.049H

物性

構造計算による物性

XLogP: -0.2
極性表面積: 38.1 Å²
水素結合供与体数: 2
水素結合受容体数: 2
回転可能結合数: 1
重原子数: 8
形式電荷: 0
複雑度: 63.5

物理化学的性質

沸点: 63 · 63-66°C/12mm
比重(密度): 0.9406 g/mL · 0.9406 g/mL at 25 °C
屈折率: 1.485 · 1.4850
闪点: 63 · 63-66°C/12mm
貯蔵温度: -20 °C · -20°C
溶解性: クロロホルム（微量）、酢酸エチル（微量）、メタノール（微量）
酸解離定数(Pka): 10.32 · 10.32±0.29(Predicted)
色: 無色透明
BRN: 102994 · 102994
InChI: InChI=1S/C6H14N2/c7-5-6-3-1-2-4-8-6/h6,8H,1-5,7H2
InChIKey: RHPBLLCTOLJFPH-UHFFFAOYSA-N
SMILES: N1CCCCC1CN
CAS データベース: 22990 · 22990-77-8(CAS DataBase Reference)

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H302 (65.5%): Harmful if swallowed [Warning Acute toxicity, oral]

P260, P264, P264+P265, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 168 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory InformationStatus: Active Update: 06-07-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/20343

Hazard Classes and CategoriesAcute Tox. 4 (65.5%)

安全データ

wgk: 2
ridadr: 2735
hs_code: 29333990
risk_code: 34
化審法: (5)-5685
消防法: 危-4-2-III
hazard_code: C
safety_code: 26-36/37/39-45
hazard_class: 8
packing_group: III
Hazard Classifications: Skin Corr. 1B
ストレージクラス: 8A - Combustible corrosive hazardous materials

化学と産業

応用分野

使用2-Piperidinemethanamine is used in the synthesis of compounds exhibiting anti-osteoclast and anti-osteoblast activity. It also is used in the synthesis of potent antibacterial.

調製方法 · 1 件

純化方法Dry (over Na2SO4) and distil the piperidine under vacuum from KOH. It has been purified via the Reinekate salt (m 173-174o) and its dipicrate salt (m 201o, from H2O). [Norton et al. J Am Chem Soc 68 1330 1946, Mortimer Aust J Chem 11 84 1958, Augustine J Am Chem Soc 81 4667 1959, Beilstein 22 III/IV 3765.]