識別子と物理属性
| CAS No. | 1402-82-0 |
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| 分子式 | C58H91N13O20 |
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| 平均分子量 | 1,290.437 g/mol |
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| 単同位体質量 | 1,289.65033231 g/mol |
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| SMILES | CCC(C)CCCCC/C=C/CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)[C@@H]1NC(=O)[C@H]2CCCCN2C1=O)C(C)C)[C@H](C)N)[C@@H](C)C(=O)O |
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| InChIKey | XBNDESPXQUOOBQ-LSMLZNGOSA-N |
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| PubChem CID | 91663250 |
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| ChEMBL | CHEMBL2103921 |
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| EC No. | 215-760-0 |
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| DTXSID | DTXSID101017657 |
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| 現地名 | アンホミシン |
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化学・物理的性質
| 比旋光度 | D25 +7.5° (c = 1 at pH 6) |
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| 沸点 | 854.06°C (rough estimate) |
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| 密度 | 1.0985 (rough estimate) |
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| 屈折率 | 1.6700 (estimate) |
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| 貯蔵条件 | Store at -20°C |
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| 溶解度 | Soluble in DMSO |
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| 外観・状態 | solid |
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| 色 | クリスタル |
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安全性と法規制
| 毒性 | LD50 orl-mus: 500 mg/kg 85GDA2 4(1),317,80 |
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用途
使用
Amphomycin is a lipopeptide antibiotic produced by Streptomycetes and Actinoplanes, initially reported by researchers at Bristol-Myers in 1953 from Streptomyces canus. Amphomycin was marketed as a complex of closely related analogues in the 1950s and 1960s. Structure elucidation was not completed until 2000. Amphomycin is active against Gram positive bacteria, inhibiting peptidoglycan synthesis and blocking cell wall development. Amphomycin is closely related to a number of “lost” antibiotics, aspartocin, crystallomycin, glumamycin, friulimicin, laspartocin, tsushimycin and zaomycin. Interest in amphomycin was re-awakened with the discovery of friulimicin activity against antibiotic resistant strains.
