ピリダジン

化学的特性Pyridazine is a nitrogen-containing six-membered heterocyclic compound belonging to the azine class, being an isomer of pyrimidine and pyrazine. It exists as a clear yellowish-brown liquid, insoluble in petroleum ether but readily soluble in methanol, ethanol, and diethyl ether. It is miscible with water, benzene, and dimethylformamide. Pyridazine is a weak base capable of forming salts with picric acid, hydrochloric acid, and similar compounds. It exhibits limited reactivity towards aromatic nucleophilic and electrophilic substitution reactions and demonstrates stability towards potassium permanganate. Reduction with sodium or alcohols cleaves the chain, converting it into 1,4-diaminobutane.

解説1,2-diazine．C4H4N2(80.09)．ピリダジンは，窒素2原子をもつ6員環芳香族複素環化合物の一つ。窒素2原子がオルト位の位置にあるのでオルトジアジンとも呼ばれた。ピリジンに似た臭気をもつ無色の液体。融点－8℃，沸点208℃。水，エチルアルコーマレインアルデヒド(2-ブテンジアール)OHCCH=CHCHOとヒドラジンH2NNH2とを縮合させると得られる．ピリジンに似た臭いをもつ無色の液体．融点－8 ℃，沸点208 ℃．d1841.107．n24D1.523．λmax 338 nm．水，エタノール，エーテル，ベンゼンに易溶，石油エーテルに不溶．ピクリン酸塩は黄色の針状晶．誘導体のサルファメトキシピリダジンはサルファ剤として用いられる。分解点170～175 ℃．森北出版「化学辞典（第2版）

用途農薬などに用いられている。

使用Pyrrolo[1,2-b]pyridazine 1 is a N-bridgehead aromatic heterocycle containing two nitrogen atoms, is obtained by the condensation of pyridazine and pyrrole.

一般的な説明Pyridazine is a mono-basic 1,2-diazine compound, which is commonly prepared by the reaction of 1,4-dicarbonyls with hydrazines. Pyridazine ring is found in many herbicides like credazine, pyridatol and many pharmaceutical drugs like cefozopran, olaparib, talazoparib, and cadralazine.