オキサロ酢酸

解説オキサロ酢酸,ケト酸の一種で，ケト形とエノール形の互変異性体がある．リンゴ酸を過マンガン酸カリウムあるいは硫酸鉄(Ⅱ)の存在下，過酸化水素で酸化するか，ジアセチル酒石酸無水物をピリジン酢酸塩で処理してヒドロキシマレイン酸無水物のピリジン塩をつくり，これを硫酸で加水分解すると得られる．結晶では完全にエノール形をしており，融点152 ℃ のシス形と184 ℃ のトランス形の2種類があり，いずれもエタノールに可溶．森北出版「化学辞典（第2版）

説明Oxaloacetic acid, also known as oxalacetic acid, is is an α-keto acid and a key component of cellular metabolism in its conjugate base form, oxaloacetate. Oxaloacetate reacts with acetyl-coenzyme A (acetyl-CoA; ) and water to form citrate in the first step of the citric acid cycle and is regenerated by oxidation of L-malate in the final step. It is an intermediate in gluconeogenesis that is formed in mitochondria via carboxylation of pyruvate and subsequently decarboxylated and phosphorylated to form phosphoenolpyruvate. It can be converted to aspartate via addition of an amino group from glutamate. Oxaloacetate (30 μmol/min per 100 g for 30 minutes, i.v.) reduces blood glutamate levels, severity of neurological dysfunction, and brain edema in a rat model of closed head injury.

使用Oxaloacetic acid is a substrate for malate dehydrogenase and oxaloacetate decarboxylase. It is an inhibitor of succinic dehydrogenase. It is four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis.

一般的な説明Oxaloacetic acid is a dicarboxylic acid. It is an intermediate in the citric acid cycle. It is highly soluble in water and is present ubiquitously. It is produced in the mitochondria by the action of pyruvate carboxylase on pyruvate. Breakdown products of oxaloacetate includes malate, pyruvate and aspartic acid.