Ethyl 4-(2-nitrophenoxy)butanoate → Ethyl 4-(2-aminophenoxy)butanoate

HRID 1003239ノート

反応式

HRID 1003239 の反応式
[N+:1]([C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[O:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])([O-])=O.[H][H]>C(OCC)(=O)C.[Pd]>[NH2:1][C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[O:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11]

参加物

5

反応物 2

HCID 12433959Ethyl 4-(2-nitrophenoxy)butanoateHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 11816929Ethyl 4-(2-aminophenoxy)butanoate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of (3) (1.27 g, 5.0 mM) in 15 mL ethyl acetate containing 200 mg of 5% palladium on carbon is reacted in a hydrogen atmosphere (40 psig.) at room temperature until hydrogen uptake ceases. The mixture is then filtered and concentrated in vacuo to yield 1.0+ g of (4) as an oil/low melting solid.

後処理

  1. filtrationThe mixture is then filtered
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-1b9a4e4c02504718852514f05c2d3592
出典データセット
uspto-grants-2000_04
特許番号
US06046183

反応ノート

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