Chloroform → 12-Iodododecylamine hydroiodide

HRID 1003307ノート

反応式

HRID 1003307 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]O.C(Cl)(Cl)Cl.[IH:19]>>[IH:19].[I:19][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH2:1]

参加物

4

反応物 3

HCID 6212ChloroformHCID 24841Hydrogen iodideHCID 518202012-Amino-1-dodecanol

生成物 1

HCID 1879642712-Iodododecylamine hydroiodide

実験手順

An aqueous solution of 100 mg of 12-aminododecanol in 57% hydriodic acid was heated under reflux for one hour. To the reaction solution was added chloroform and the mixture was washed successively with water, a 10% aqueous solution of sodium thiosulfate and a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was distilled off and the residue thus obtained was chromatographed over a silica gel column to afford 171 mg of the title compound.

後処理

  1. temperatureunder reflux for one hour
  2. washthe mixture was washed successively with water
  3. dry with materiala 10% aqueous solution of sodium thiosulfate and a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate
  4. distillationThe solvent was distilled off
  5. customthe residue thus obtained
  6. customwas chromatographed over a silica gel column

出典と根拠

ORDレコード
ord-8c38f6e4b61b4f4e9b472ebd6d0b9738
出典データセット
uspto-grants-2000_04
特許番号
US06046201

反応ノート

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