Hydrochloric Acid → 5-Methoxybenzo[d]isoxazol-3-amine
反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([O:11][N:12]=C(C)C)=[C:7]([CH:10]=1)[C:8]#[N:9].Cl.C(=O)([O-])[O-].[Na+].[Na+]>CO>[NH2:9][C:8]1[C:7]2[CH:10]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=2[O:11][N:12]=1参加物
5
実験手順
In 125 ml of dry methanol was dissolved 5-methoxy-2-[[(1-methylethylidene)-amino]oxy]benzonitrile (10 g), followed by 125 ml of ethereal hydrochloric acid. The reaction was stirred under nitrogen overnight. The reaction was neutralized with saturated sodium carbonate solution and extracted with EtOAc. The organic layer was dried and concentrated in vacuo. Recrystallization of the residue from dichloromethane/petroleum ether afforded the expected product (6.8 g).
後処理
- extractionextracted with EtOAc
- customThe organic layer was dried
- concentrationconcentrated in vacuo
- customRecrystallization of the residue from dichloromethane/petroleum ether
出典と根拠
- ORDレコード
- ord-da1a881ec815489fb21708ec556b868c
- 出典データセット
- uspto-grants-2000_04
- 特許番号
- US06046203
反応ノート
読み込み中…