p-Xylyl bromide → S-p-Methylbenzyl-L-cysteine

HRID 1003649ノート

反応式

HRID 1003649 の反応式
O.Cl.[NH2:3][C@H:4]([C:7]([OH:9])=[O:8])[CH2:5][SH:6].Br[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=1>[OH-].[Na+].C(O)C>[CH3:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][S:6][CH2:5][C@@H:4]([C:7]([OH:9])=[O:8])[NH2:3])=[CH:14][CH:13]=1

参加物

5

反応物 2

HCID 7721p-Xylyl bromideHCID 23462L-Cysteine hydrochloride monohydrate

生成物 1

HCID 13994756S-p-Methylbenzyl-L-cysteine

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

L-Cysteine hydrochloride monohydrate (2.0 g) is dissolved in a 2 N aqueous sodium hydroxide solution (11.4 ml). To the solution is added a solution of α-bromo-p-xylene (2.3 g) in ethanol (10 ml). The mixture is stirred at room temperature for 40 minutes, and precipitating crystals are filtered off. The obtained crystals are purified by recrystallization to give the titled compound.

後処理

  1. customprecipitating crystals
  2. filtrationare filtered off
  3. customThe obtained crystals are purified by recrystallization

出典と根拠

ORDレコード
ord-2bd0214789884754b1d748c3c1b81b2a
出典データセット
uspto-grants-2000_04
特許番号
US06046235

反応ノート

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