p-Toluenesulfonic acid → 2-Tetralone-6-carboxamide
反応式
C1O[C:4]2([CH2:13][CH2:12][C:11]3[C:6](=[CH:7][CH:8]=[C:9]([C:14]([NH2:16])=[O:15])[CH:10]=3)[CH2:5]2)[O:3]C1.C1(C)C=CC(S(O)(=O)=O)=CC=1>CC(C)=O>[CH2:5]1[C:6]2[C:11](=[CH:10][C:9]([C:14]([NH2:16])=[O:15])=[CH:8][CH:7]=2)[CH2:12][CH2:13][C:4]1=[O:3]参加物
4
実験手順
2-Tetralone-6-carboxamide ethylene ketal (250 mg, 1.07 mmol) and catalytic p-toluenesulfonic acid were stirred in acetone (50 mL) at ambient temperature for 48 hours. The volatiles were removed in vacuo and the residue triturated in ethyl acetate. The solids were filtered, washed and dried to yield 77.5 mg (38%) of 2-Tetralone-6-carboxamide as a white powder, pure by NMR, TLC. MS.
後処理
- customThe volatiles were removed in vacuo
- customthe residue triturated in ethyl acetate
- filtrationThe solids were filtered
- washwashed
- customdried
出典と根拠
- ORDレコード
- ord-f98270f4f7454820ac088ef9de76b3e8
- 出典データセット
- uspto-grants-2000_04
- 特許番号
- US06046227
反応ノート
読み込み中…