Hydrogen Bromide → 5-Iodobenzene-1,3-diol

HRID 1003945

反応式

HRID 1003945 の反応式
C[O:2][C:3]1[CH:4]=[C:5]([I:11])[CH:6]=[C:7]([O:9]C)[CH:8]=1.Br>C(O)(=O)C>[OH:2][C:3]1[CH:4]=[C:5]([I:11])[CH:6]=[C:7]([OH:9])[CH:8]=1

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 6401791-Iodo-3,5-dimethoxybenzene

生成物 1

HCID 6167555-Iodobenzene-1,3-diol収率 99.7%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

3,5-Dimethoxyiodobenzene (1.19 g) is dissolved in acetic acid (10 ml), and thereto is added 47% hydrobromic acid (10 ml) at room temperature, and the mixture is refluxed for 15 hours. The reaction mixture is cooled to room temperature, and concentrated to dryness under reduced pressure. The residue is dissolved in ethyl acetate, and the organic layer is washed with water, dried, and concentrated under reduced pressure to give 3,5-dihydroxyiodobenzene (1.06 g).

後処理

  1. temperaturethe mixture is refluxed for 15 hours
  2. concentrationconcentrated to dryness under reduced pressure
  3. dissolutionThe residue is dissolved in ethyl acetate
  4. washthe organic layer is washed with water
  5. customdried
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-82fa8e9a43cd431faf20c55195195adb
出典データセット
uspto-grants-2000_04
特許番号
US06048842

関連ノート

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