Acetyl chloride → N-Methyl-phenylglycine methyl ester hydrochloride

HRID 1003960

反応式

HRID 1003960 の反応式
[CH3:1][N:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:3][C:4]([OH:6])=[O:5].[C:13]([Cl:16])(=O)C>CO>[ClH:16].[CH3:13][O:5][C:4](=[O:6])[CH2:3][N:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:1]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 420843N-Methyl-N-phenyl-glycine

生成物 1

HCID 70291077N-Methyl-phenylglycine methyl ester hydrochloride収率 94%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Prepared by Method A of Example 19 but using N-methyl-phenylglycine (prepared in turn from 2-chlorophenylacetic acid and methylamine) (3.5 g) methanol (20 ml) and acetyl chloride (40 ml) over 48 hours. The title compound was obtained in 94% yield, after trituration with methanol, as a white solid.

後処理

  1. customPrepared by Method A of Example 19
  2. customover 48 hours

出典と根拠

ORDレコード
ord-3f0ae84401de4753b2d31985f3ef5bd9
出典データセット
uspto-grants-2000_04
特許番号
US06048852

関連ノート

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