Triethylamine → HCID 18794251、化合物
反応式
[CH3:1][C:2]1[NH:16][CH2:15][CH2:14][C:4]2=[C:5]3[C:10](=[N:11][C:3]=12)[CH:9]=[CH:8][C:7]([O:12][CH3:13])=[CH:6]3.C(N(CC)CC)C.Cl[C:25]([O:27][CH2:28][CH3:29])=[O:26]>ClCCl>[CH2:1]=[C:2]1[C:3]2[NH:11][C:10]3[C:5](=[CH:6][C:7]([O:12][CH3:13])=[CH:8][CH:9]=3)[C:4]=2[CH2:14][CH2:15][N:16]1[C:25]([O:27][CH2:28][CH3:29])=[O:26]参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a solution of 10-methoxyharmalan in dichloro-methane is added triethylamine (1.5 eq) and the mixture is cooled to 0° C. A solution (1/5 v/v) of ethyl chloro-formate in dichloromethane is then added dropwise. The mixture is stirred at 0° C. until the starting material disappears (2 h). After evaporation of the solvent, the crude product is separated out on a chromatography plate (eluent: EtOAc/pet. ether; 50/50).