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Water → 4'-Bromo-4-carboxymethylbiphenyl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | 1-(4'-Bromo(1,1'-biphenyl)-4-yl)ethan-1-one | HCID 79806 | — |
| 反応物 | Sulfur | HCID 5362487 | — |
| 生成物 | 4'-Bromo-4-carboxymethylbiphenyl | HCID 1394245 | — |
反応手順
The compound (3 g) obtained in the above (1) is suspended in morpholine (20 ml), and thereto is added sulfur (0.71 g), and the mixture is refluxed with stirring for five hours. After cooling, the reaction mixture is poured into water, and extracted with ethyl acetate. The organic layer is washed with 1N hydrochloric acid (twice) and a saturated brine (twice), and dried over anhydrous sodium sulfate. The desiccant is removed by filtration, and the filtrate is concentrated under reduced pressure. The residue is suspended in ethanol, and the precipitates are collected by filtration.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06048854 |
| 出典データセット | uspto-grants-2000_04 |
| ORD ID | ord-78e0cf40f386481aa4f06f0069be9b7d |
| 出典メモ | uspto-grants-2000_04 |