反应详情

The compound (3 g) obtained in the above (1) is suspended in morpholine (20 ml), and thereto is added sulfur (0.71 g), and the mixture is refluxed with stirring for five hours. After cooling, the reaction mixture is poured into water, and extracted with ethyl acetate. The organic layer is washed with 1N hydrochloric acid (twice) and a saturated brine (twice), and dried over anhydrous sodium sulfate. The desiccant is removed by filtration, and the filtrate is concentrated under reduced pressure. The residue is suspended in ethanol, and the precipitates are collected by filtration.

1. temperaturethe mixture is refluxed
2. temperatureAfter cooling
3. extractionextracted with ethyl acetate
4. washThe organic layer is washed with 1N hydrochloric acid (twice) and a saturated brine (twice), and
5. dry with materialdried over anhydrous sodium sulfate
6. customThe desiccant is removed by filtration
7. concentrationthe filtrate is concentrated under reduced pressure
8. filtrationthe precipitates are collected by filtration