Hydrochloric Acid → 4-Fluoro-5-(pyrrolidin-1-yl)-1,2-phenylenediamine
反応式
[N+:1]([C:4]1[CH:10]=[C:9]([F:11])[C:8]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:7][C:5]=1[NH2:6])([O-])=O.Cl>[Fe].C(O)C>[F:11][C:9]1[C:8]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:7][C:5]([NH2:6])=[C:4]([NH2:1])[CH:10]=1参加物
5
実験手順
The nitroaniline derivative (5.0 g, 0.022 mol) (obtained in step 1 above) was reduced using Fe powder (12.6 g, 0.22 mol), conc. HCl (33 mL) and ethanol (33 mL) as described in preparation 10 (step 2) to yield 4-fluoro-5-(pyrrolidin-1-yl)-1,2-phenylenediamine (4.2 g, 97%) as viscous oil. IR (Neat) 3340, 1524 cm-1 ; 1H NMR (CDCl3) δd 1.93 (m, 4H, (CH2)2), 3.24 (m, 4H, N(CH2)2), 3.56 (brs, 4H, 2×NH2), 6.18 (d, J=7.2 Hz, 1H), 6.48 (d, J=13.2 Hz, 1H); Mass (m/z) 195 (M+.).
後処理
- customas described in preparation 10 (step 2)
出典と根拠
- ORDレコード
- ord-b46afbc171b94574a57d51db5cd8c78c
- 出典データセット
- uspto-grants-2000_04
- 特許番号
- US06051570
反応ノート
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