Toluene → 3-(2-Bromoethoxy)-4-methylthiophene

HRID 1004728ノート

反応式

HRID 1004728 の反応式
[CH3:1][O:2][C:3]1[C:7]([CH3:8])=[CH:6][S:5][CH:4]=1.C1(C)C=CC=CC=1.[Br:16][CH2:17]CO.OS([O-])(=O)=O.[Na+]>CO>[Br:16][CH2:17][CH2:1][O:2][C:3]1[C:7]([CH3:8])=[CH:6][S:5][CH:4]=1

参加物

6

反応物 4

HCID 1140TolueneHCID 108982-BromoethanolHCID 516919Sodium BisulfateHCID 130618593-Methoxy-4-methylthiophene

生成物 1

HCID 220163383-(2-Bromoethoxy)-4-methylthiophene収率 55%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

4.2 g of 3-methoxy-4-methylthiophene was added to a mixture of 40 mL of toluene, 8.2 g of 2-bromo-1-ethanol (Aldrich) and 500 mg of NaHSO4. The resulting mixture was heated until the produced methanol had been distilled off and the temperature rose to 110° C. The product was cooled and washed several times with water and, subsequently, extracted with diethyl ether. The organic phase was dried with magnesium sulfate and then evaporated. The product was purified by column chromatography using silica gel and hexanes as eluent. Yield=55%.

後処理

  1. distillationhad been distilled off
  2. customrose to 110° C
  3. temperatureThe product was cooled
  4. washwashed several times with water
  5. extractionsubsequently, extracted with diethyl ether
  6. dry with materialThe organic phase was dried with magnesium sulfate
  7. customevaporated
  8. customThe product was purified by column chromatography

出典と根拠

ORDレコード
ord-51ba08416c1b46cba85097dc2d86280d
出典データセット
uspto-grants-2000_04
特許番号
US06051679

反応ノート

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