Oxalyl chloride → 2-Chlorobenzoyl isocyanate

HRID 1004866

反応式

HRID 1004866 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:12](Cl)=[O:13]>ClCCCl>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([N:6]=[C:12]=[O:13])=[O:5]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 691112-Chlorobenzamide

生成物 1

HCID 99423112-Chlorobenzoyl isocyanate

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

反応条件

温度
100 °C

実験手順

0.47 g (3.0 mmol) of 2-chlorobenzamide and 0.40 g (3.2 mmol, 1.05 eq) of oxalyl chloride were added to 10 ml of 1,2-dichloroethane and then the mixture was stirred for 8 hours at 100° C. The reaction solution was cooled down to room temperature. The reaction solvent and excessive oxalyl chloride were removed by distillation under reduced pressure to obtain 2-chlorobenzoyl isocyanate in an oily state. 10 ml of fresh 1,2-dichloroethane and 0.95 g (3.0 mmol) of 2,4-dibromo-5-trifluoromethyl aniline were successively added thereto, reacted for 2 hours and filtered to obtain 1.2 g (Yield 80%) of the title compound as a solid.

後処理

  1. temperatureThe reaction solution was cooled down to room temperature
  2. customThe reaction solvent and excessive oxalyl chloride were removed by distillation under reduced pressure

出典と根拠

ORDレコード
ord-037dbbb3933e41b3a06e153abe7f5bea
出典データセット
uspto-grants-2000_04
特許番号
US06051737

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