Hydrogen Bromide → 6-(Bromomethyl)isoquinoline hydrobromide
反応式
[CH:1]1[C:10]2[C:5](=[CH:6][C:7]([CH2:11]O)=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.[BrH:13].C(OCC)C>C(O)(=O)C>[BrH:13].[Br:13][CH2:11][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[CH:1]=[N:2][CH:3]=[CH:4]2参加物
5
反応条件
- 温度
- 70 °C
実験手順
A solution of 190 mg (1.19 mmol) of 6-isoquinoline-methanol in 1 ml of glacial acetic acid was treated with 2 ml of 30% HBr in glacial acetic acid and the mixture was heated at 70° C. for 45 minutes. The reaction mixture was cooled, treated with 20 ml of diethyl ether and stirred at 0° C. for 30 min. The resulting solid was filtered off, washed with diethyl ether and dried in a high vacuum. There was obtained 6-bromomethyl-isoquinoline hydrobromide (73% of theory) as a light brown solid; MS: 221, 223 (M)+.
後処理
- temperatureThe reaction mixture was cooled
- filtrationThe resulting solid was filtered off
- washwashed with diethyl ether
- customdried in a high vacuum
出典と根拠
- ORDレコード
- ord-60e92c6d2c1a458ea2be33586a7c2509
- 出典データセット
- uspto-grants-2000_04
- 特許番号
- US06051712
反応ノート
読み込み中…