Borane → HCID 22127280、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][N:11]([CH3:14])[CH2:12][CH:13]=2)=[CH:4][CH:3]=1.B.[O:16]1CCCC1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:9][CH2:10][N:11]([CH3:14])[CH2:12][CH:13]2[OH:16])=[CH:4][CH:3]=1参加物
4
実験手順
In an analogous manner to that described in Example 1(c), from 4-(4-chloro-phenyl)-1-methyl-1,2,3,6-tetrahydropyridine [U.S. Pat. No. 3,320,265] by hydroboration using borane in tetrahydrofuran there was obtained (3RS,4RS)-4-(4-chloro-phenyl)-1-methyl-piperidin-3-ol which, after recrystallization from a mixture of methylene chloride and hexane, formed colourless crystals of m.p.: 99-100° C.
出典と根拠
- ORDレコード
- ord-2faba196a32d427297e99e54c0eb0ea0
- 出典データセット
- uspto-grants-2000_04
- 特許番号
- US06051712
反応ノート
読み込み中…