Nitric Acid → 3-(4-Chloro-3-nitrophenyl)-1-methyl-4,5-di(trifluoromethyl)-1H-pyrazole
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]([F:16])([F:15])[F:14])=[C:11]([C:17]([F:20])([F:19])[F:18])[N:10]([CH3:21])[N:9]=2)=[CH:4][CH:3]=1.[N+:22]([O-])([OH:24])=[O:23]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([C:13]([F:15])([F:16])[F:14])=[C:11]([C:17]([F:20])([F:18])[F:19])[N:10]([CH3:21])[N:9]=2)=[CH:4][C:3]=1[N+:22]([O-:24])=[O:23]参加物
3
反応条件
- 温度
- 0 °C
実験手順
9 g (27 mmol) of 3-(4-chlorophenyl)-1-methyl-4,5-di(trifluoromethyl)-1H-pyrazole were added at (-40)° C. to 100 ml of concentrated nitric acid, whereupon the mixture was stirred for 2 hours at this temperature. The solution, which was subsequently warmed to 0° C., was treated with ice-water. The product was subsequently extracted with methyl tert-butyl ether. The organic phase was washed with water, dried over magnesium sulfate and concentrated.
後処理
- extractionThe product was subsequently extracted with methyl tert-butyl ether
- washThe organic phase was washed with water
- dry with materialdried over magnesium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-2a98118533e94f3ea0b49942b5ff8ade
- 出典データセット
- uspto-grants-2000_04
- 特許番号
- US06054412
反応ノート
読み込み中…