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Carbamate → 5-(3,5-Dichlorophenylthio)-1-ethyl-4-isopropyl-1H-imidazol-2-ylmethyl palmitoylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Carbamate | HCID 276 | — |
| 反応物 | (5-(3,5-Dichlorophenylthio)-1-ethyl-4-isopropyl-1H-imidazol-2-yl)methanol | HCID 473933 | — |
| 反応物 | Palmitoyl isocyanate | HCID 18792000 | — |
| 生成物 | 5-(3,5-Dichlorophenylthio)-1-ethyl-4-isopropyl-1H-imidazol-2-ylmethyl palmitoylcarbamate | HCID 69686480 | 57% |
反応手順
The compound 19 (250 mg, 0.725 mmol) was converted to the carbamate with palmitoyl isocyanate (5 eq.) in the same manner as the example 66 to give the compound 85 (259 mg, 57%). Mp. 95-97° C. Rf 0.33 (1:2 EtOAc - hexane).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06054591 |
| 出典データセット | uspto-grants-2000_04 |
| ORD ID | ord-5d912f3f93464a7dbab55e98775b76b9 |
| 出典メモ | uspto-grants-2000_04 |