Sodium Hydroxide → 3-methoxy-4-nitro-N-[2-(5-carboxypent-1-yloxy)-4-methylphenyl]-N-methylbenzamide

HRID 1005579ノート

反応式

HRID 1005579 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:28]=[CH:29][C:30]=1[N+:31]([O-:33])=[O:32])[C:6]([N:8]([C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:11]=1[O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]([O:25]CC)=[O:24])[CH3:9])=[O:7].[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:28]=[CH:29][C:30]=1[N+:31]([O-:33])=[O:32])[C:6]([N:8]([C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:11]=1[O:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])[CH3:9])=[O:7]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 220107713-methoxy-4-nitro-N-[2-(5-ethoxycarbonylpent-1-yloxy)-4-methylphenyl]-N-methylbenzamide

生成物 1

HCID 187914763-methoxy-4-nitro-N-[2-(5-carboxypent-1-yloxy)-4-methylphenyl]-N-methylbenzamide収率 99.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 3-methoxy-4-nitro-N-[2-(5-ethoxycarbonylpent-1-yloxy)-4-methylphenyl]-N-methylbenzamide (7.6 g) in ethanol (76 ml) was treated with 1 N sodium hydroxide solution (33 ml) at ambient temperature and the mixture was stirred at the same temperature for 6 hours. The reaction was quenched by the dropwise addition of 1 N hydrochloric acid (35 ml). The mixture was concentrated and the residue was dissolved in a mixture of ethyl acetate and 1 N hydrochloric acid. The extracted organic layer was washed with brine and dried over magnesium sulfate. The suspension was filtered and the solvent was removed by evaporation to give 3-methoxy-4-nitro-N-[2-(5-carboxypent-1-yloxy)-4-methylphenyl]-N-methylbenzamide (7.1 g) as an oil.

後処理

  1. customThe reaction was quenched by the dropwise addition of 1 N hydrochloric acid (35 ml)
  2. concentrationThe mixture was concentrated
  3. dissolutionthe residue was dissolved in a mixture of ethyl acetate and 1 N hydrochloric acid
  4. washThe extracted organic layer was washed with brine
  5. dry with materialdried over magnesium sulfate
  6. filtrationThe suspension was filtered
  7. customthe solvent was removed by evaporation

出典と根拠

ORDレコード
ord-5987305824104f4c97bc0c8503d80798
出典データセット
uspto-grants-2000_04
特許番号
US06054457

反応ノート

読み込み中…