Water → HCID 22674130、化合物

HRID 1005677ノート

反応式

HRID 1005677 の反応式
[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7](Cl)(=[O:9])=[O:8])=[CH:3][CH:2]=1.O.[NH2:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[CH:20]=[N:19][CH:18]=[CH:17]2>N1C=CC=CC=1>[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7]([NH:13][C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[CH:20]=[N:19][CH:18]=[CH:17]3)(=[O:9])=[O:8])=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 962WaterHCID 73974-Toluenesulfonyl chlorideHCID 5889916-Aminoisoquinoline

生成物 1

HCID 22674130HCID 22674130、化合物収率 85%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

In pyridine (30 ml) was dissolved 6-aminoisoquinoline (3.348 g, Synthesis, 733 (1975), and 4-toluenesulfonyl chloride (5.13 g) was added thereto, followed by stirring at room temperature overnight. Water was added thereto, followed by extracting with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evaporated. The residue was recrystallized from ethanol, to give the title compound (5.958 g, 85%) as pale yellow crystals.

後処理

  1. additionwas added
  2. extractionby extracting with ethyl acetate
  3. washThe extract was washed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated
  6. customThe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-02b335e5e83e4f408646d80e2e6466cf
出典データセット
uspto-grants-2004_09
特許番号
US06787534B2

反応ノート

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