Water → N-(3-Nitrophenethyl)acetamide

HRID 1005682ノート

反応式

HRID 1005682 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[CH2:7][CH2:8][NH2:9])([O-:3])=[O:2].[C:13](Cl)(=[O:15])[CH3:14].O>N1C=CC=CC=1>[C:13]([NH:9][CH2:8][CH2:7][C:6]1[CH:10]=[CH:11][CH:12]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)(=[O:15])[CH3:14]

参加物

5

反応物 3

HCID 962WaterHCID 6367Acetyl chlorideHCID 129500662-(3-Nitrophenyl)ethan-1-amine

生成物 1

HCID 22674066N-(3-Nitrophenethyl)acetamide収率 91%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

In pyridine (33 ml) was dissolved 5.559 g of 3-nitrophenethylamine (Preparation Example 25), followed by dropwise addition of acetyl chloride (2.5 ml) under ice-cooling. After stirring at room temperature for 0.5 hour, the mixture was again ice-cooled. Water was added thereto, followed by extracting with ethyl acetate, The extract was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give the title compound (6.323 g, 91%) as a yellow oil.

後処理

  1. temperaturecooling
  2. temperaturecooled
  3. extractionby extracting with ethyl acetate
  4. washThe extract was washed with brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-ade47436397045c8b8662a77d6fcc02a
出典データセット
uspto-grants-2004_09
特許番号
US06787534B2

反応ノート

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