Sodium Hydroxide → 1-Methylisoquinolin-6-amine

HRID 1005687ノート

反応式

HRID 1005687 の反応式
C(OC([NH:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[C:13]([CH3:17])=[N:12][CH:11]=[CH:10]2)=O)C.[OH-].[Na+].[Cl-].[NH4+]>C(O)C>[NH2:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[C:13]([CH3:17])=[N:12][CH:11]=[CH:10]2

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 25517Ammonium ChlorideHCID 226741466-Ethoxycarbonylamino-1-methylisoquinoline

生成物 1

HCID 226740791-Methylisoquinolin-6-amine収率 72%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In ethanol (20 ml) was dissolved 0.629 g of 6-ethoxycarbonylamino-1-methylisoquinoline (Preparation Example 32), and 8 N sodium hydroxide aqueous solution (6.8 ml), followed by heating under reflux for 1.5 hours. After cooling as it was to room temperature, an aqueous saturated ammonium chloride was added thereto, followed by extracting with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give the title compound (0.311 g, 72%) as pale yellow crystals.

後処理

  1. temperatureby heating
  2. temperatureunder reflux for 1.5 hours
  3. temperatureAfter cooling as it
  4. customwas to room temperature
  5. extractionby extracting with ethyl acetate
  6. washThe extract was washed with brine
  7. dry with materialdried over anhydrous magnesium sulfate
  8. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-c6d1b7d673704c1aba24c2f6203a9b2d
出典データセット
uspto-grants-2004_09
特許番号
US06787534B2

反応ノート

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