Sodium borohydride → 2-(3-Nitrophenyl)propan-1-ol
反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]([CH3:13])[CH:11]=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[BH4-].[Na+]>C(O)C.[Cl-].[Na+].O>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]([CH3:13])[CH2:11][OH:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]参加物
5
実験手順
In ethanol (100 ml) was dissolved 7.531 g of 2-(3-nitrophenyl)propanal. Under ice-cooling, sodium borohydride (1.9 g) was added thereto, followed by stirring at room temperature for 1 hour. To the mixture was added brine, followed by extracting with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and the solvent was evaporated. The resulting residue was purified by silica gel column, to give the title compound (6.275 g, 57.19% in 3 steps) as a brown oil.
後処理
- temperatureUnder ice-cooling
- extractionby extracting with ethyl acetate
- washThe extract was washed with brine
- dry with materialdried over anhydrous magnesium sulfate
- customthe solvent was evaporated
- customThe resulting residue was purified by silica gel column
出典と根拠
- ORDレコード
- ord-543be03fe5f2456598ae6c2ad0529112
- 出典データセット
- uspto-grants-2004_09
- 特許番号
- US06787534B2
反応ノート
読み込み中…