Pyridine-3-sulfonyl chloride → HCID 10292214、化合物

HRID 1005693ノート

反応式

HRID 1005693 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([S:7](Cl)(=[O:9])=[O:8])[CH:2]=1.[NH2:11][C:12]1[CH:13]=[N:14][C:15]2[C:20]([CH:21]=1)=[CH:19][CH:18]=[CH:17][C:16]=2[Br:22]>N1C=CC=CC=1>[Br:22][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:15]=1[N:14]=[CH:13][C:12]([NH:11][S:7]([C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)(=[O:9])=[O:8])=[CH:21]2

参加物

4

反応物 2

HCID 3164136Pyridine-3-sulfonyl chlorideHCID 226741618-Bromoquinolin-3-amine

生成物 1

HCID 10292214HCID 10292214、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒2 回

実験手順

In pyridine (5 ml) was dissolved 3-amino-8-bromoquinoline (Preparation Example 5) was dissolved in pyridine (5 ml), and 3-pyridinesulfonyl chloride (254 mg) was added thereto, followed by stirring at room temperature for 30 minutes. After the completion of the reaction, the reaction mixture was poured onto brine, and extracted with ethyl acetate. The organic layer was dried over magnesium sulfate and then concentrated. The resulting crude crystals were washed with ethyl acetate and IPA, to give the title compound (270 mg).

後処理

  1. customAfter the completion of the reaction
  2. additionthe reaction mixture was poured onto brine
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic layer was dried over magnesium sulfate
  5. concentrationconcentrated
  6. washThe resulting crude crystals were washed with ethyl acetate and IPA

出典と根拠

ORDレコード
ord-8380505b3fff4ff09bb58d17a94a55ad
出典データセット
uspto-grants-2004_09
特許番号
US06787534B2

反応ノート

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