Pyridine → HCID 22674187、化合物

HRID 1005695ノート

反応式

HRID 1005695 の反応式
N1C=CC=CC=1.[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([S:14](Cl)(=[O:16])=[O:15])=[CH:10][CH:9]=1.[NH2:18][C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][C:25]=2[Cl:29])[N:20]=1>O>[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([S:14]([NH:18][C:19]2[CH:28]=[CH:27][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][C:25]=3[Cl:29])[N:20]=2)(=[O:16])=[O:15])=[CH:10][CH:9]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 73984-Chlorobenzenesulfonyl chlorideHCID 140674265-Chloroquinolin-2-amine

生成物 1

HCID 22674187HCID 22674187、化合物収率 8.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Pyridine (1 ml) and 4-chlorobenzenesulfonyl chloride (255 mg) were added to 2-amino-5-chloroquinoline (119 mg, Preparation Example 2) at room temperature. After stirring at room temperature for 3 days, water was added thereto and the mixture was extracted with ethyl acetate. The ethyl acetate layer was dried over sodium sulfate and concentrated. Then, the resulting solid was washed with methanol, to give the title compound (20 mg).

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe ethyl acetate layer was dried over sodium sulfate
  3. concentrationconcentrated
  4. washThen, the resulting solid was washed with methanol

出典と根拠

ORDレコード
ord-5ff07c5c102b42ff9ce5f9e6d1eb24e8
出典データセット
uspto-grants-2004_09
特許番号
US06787534B2

反応ノート

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