Water → HCID 59083366、化合物

HRID 1005698ノート

反応式

HRID 1005698 の反応式
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([Br:12])=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1.O>N1C=CC=CC=1>[Br:12][C:6]1[C:5]2[C:10](=[CH:11][C:2]([NH:1][S:20]([C:17]3[CH:18]=[CH:19][C:14]([Cl:13])=[CH:15][CH:16]=3)(=[O:22])=[O:21])=[CH:3][CH:4]=2)[CH:9]=[N:8][CH:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 73984-Chlorobenzenesulfonyl chlorideHCID 226740574-Bromo-7-isoquinolinamine

生成物 1

HCID 59083366HCID 59083366、化合物収率 36.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

In 1.5 ml of pyridine was dissolved 20 mg (0.09 mmol) of 7-amino-4-bromoisoquinoline (Preparation Example 20), 23 mg of 4-chlorobenzenesulfonyl chloride was added thereto, followed by stirring at room temperature overnight. To the reaction mixture was added water, followed by extracting with ethyl acetate. The extract was dried over magnesium sulfate and concentrated. Then, the resulting residue was purified by silica gel thin layer chromatography, to give 13 mg of the title compound. Melting point: gradually decomposed from 229 degrees.

後処理

  1. additionwas added
  2. extractionby extracting with ethyl acetate
  3. dry with materialThe extract was dried over magnesium sulfate
  4. concentrationconcentrated
  5. customThen, the resulting residue was purified by silica gel thin layer chromatography

出典と根拠

ORDレコード
ord-34de48a57a364b019add73319d38723c
出典データセット
uspto-grants-2004_09
特許番号
US06787534B2

反応ノート

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