Toluene → 2-(5-Hydroxypentyloxy)pyridine
反応式
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[OH-:8].[K+].C1[O:27][CH2:26][CH2:25]OCCOCCOCCOCCOC1.[C:28]1([CH3:34])C=CC=C[CH:29]=1>O>[OH:8][CH2:29][CH2:28][CH2:34][CH2:25][CH2:26][O:27][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1参加物
6
実験手順
10.5 g of 1,5-pentadiol, 5.68 g of 2-chloropyridine, 5.6 g of KOH and 5.3 g of 18-crown-6-ether were added to 20 ml of toluene and the mixture was refluxed for 8 hours. After cooling, the reaction mixture was added with water and extracted with chloroform. The extract was dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane) to obtain 6.5 g of the title compound (yield: 72%).
後処理
- temperaturethe mixture was refluxed for 8 hours
- temperatureAfter cooling
- extractionextracted with chloroform
- dry with materialThe extract was dried over sodium sulfate
- customthe solvent was evaporated under reduced pressure
- customThe resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane)
出典と根拠
- ORDレコード
- ord-383e6f3912b1434da7f83e964a6cd4bf
- 出典データセット
- uspto-grants-2004_09
- 特許番号
- US06787561B1
反応ノート
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