Ethyl 2-[4-(2-benzyloxyethyl)phenoxy]-2-methylpropionate → Ethyl 2-[4-(2-hydroxy-ethyl)-phenoxy]-2-methyl-propionate

HRID 1006453ノート

反応式

HRID 1006453 の反応式
C([O:8][CH2:9][CH2:10][C:11]1[CH:25]=[CH:24][C:14]([O:15][C:16]([CH3:23])([CH3:22])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13][CH:12]=1)C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:15][C:16]([CH3:22])([CH3:23])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:24][CH:25]=1

参加物

4

反応物 1

HCID 15453494Ethyl 2-[4-(2-benzyloxyethyl)phenoxy]-2-methylpropionate

生成物 1

HCID 15229879Ethyl 2-[4-(2-hydroxy-ethyl)-phenoxy]-2-methyl-propionate収率 87.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of ethyl 2-[4-(2-benzyloxyethyl)-phenoxy]-2-methylpropionate (480 mg) in ethanol (3.0ml) was added 10% palladium on activated carbon (30 mg), and the mixture was stirred for 48 hours at room temperature under a hydrogen atmosphere. The catalyst was filtered off, and the solvent of the filtrate was removed under reduced pressure. Purification of the residue by medium pressure liquid column chromatography on silica gel (eluent: hexane/diethyl ether=1/1) gave ethyl 2-[4-(2-hydroxyethyl)phenoxy]-2-methylpropionate (310 mg).

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe solvent of the filtrate was removed under reduced pressure
  3. customPurification of the residue by medium pressure liquid column chromatography on silica gel (eluent: hexane/diethyl ether=1/1)

出典と根拠

ORDレコード
ord-57a19fd0a65a41a0ade8ba84f4e83072
出典データセット
uspto-grants-2004_09
特許番号
US06790865B2

反応ノート

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