Hydrochloric Acid → 2-[3-chloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]-2-methylpropionic acid

To a solution of ethyl 2-[3-Chloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-phenoxy]-2-methylpropionate (2.39 g) in ethanol (20 ml) was added 2N aqueous sodium hydroxide solution (8.2 ml ), and the mixture was stirred for 13 hours at room temperature. To the stirred reaction mixture was added 2N hydrochloric acid (8.2 ml) under ice-cooling. After the reaction mixture was concentrated under reduced pressure, azeotropic concentration with ethanol was undergone. The residue was washed with water (180 ml) and dried under reduced pressure to give 2-[3-chloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]-2-methylpropionic acid (2.02 g).

1. customTo the stirred reaction mixture
2. temperaturecooling
3. concentrationAfter the reaction mixture was concentrated under reduced pressure, azeotropic concentration with ethanol
4. washThe residue was washed with water (180 ml)
5. customdried under reduced pressure

ORDレコード

ord-954b37d9237d4a7dbd1ce9d352658d40

出典データセット

uspto-grants-2004_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06790865B2