Ammonium Chloride → HCID 178461804、化合物

HRID 1006511ノート

反応式

HRID 1006511 の反応式
[Na].[NH2:2][C:3]1[S:4][C:5]2[C:10]([NH:11][C@H:12]([CH3:15])[CH2:13][OH:14])=[N:9][C:8]([S:16]CC3C=CC=CC=3)=[N:7][C:6]=2[N:24]=1.[Cl-].[NH4+]>N>[NH2:2][C:3]1[S:4][C:5]2[C:10]([NH:11][C@H:12]([CH3:15])[CH2:13][OH:14])=[N:9][C:8]([SH:16])=[N:7][C:6]=2[N:24]=1

参加物

5

反応物 3

HCID 25517Ammonium ChlorideHCID 5360545SodiumHCID 11857680(2R)-2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol

生成物 1

HCID 178461804HCID 178461804、化合物

試薬・触媒・溶媒 1

HCID 222Ammonia溶媒

実験手順

Sodium metal was added portionwise to a solution of the product of example 32 step a) (5.0 g) in ammonia (150 ml) until a blue colouration persisted. Ammonium chloride was then added and the solvent allowed to evaporate. The residue was dissolved in H2O (200 ml) and filtered before neutralising with 2M HCl solution. The grey precipitate was filtered, washed with H2O (200 ml) and dried in vacuo for 48 h to yield the subtitle compound as a brown solid (3.0 g).

後処理

  1. customto evaporate
  2. dissolutionThe residue was dissolved in H2O (200 ml)
  3. filtrationfiltered
  4. filtrationThe grey precipitate was filtered
  5. washwashed with H2O (200 ml)
  6. customdried in vacuo for 48 h

出典と根拠

ORDレコード
ord-c3367a14331a4c2d9b723709b62417a9
出典データセット
uspto-grants-2004_09
特許番号
US06790850B1

反応ノート

読み込み中…